Lis, N.; Lamnisos, D.; Bograkou-Tzanetakou, A.; Hadjimbei, E.; Tzanetakou, I.P. Preterm Birth and Its Association with Maternal Diet, and Placental and Neonatal Telomere Length. Nutrients2023, 15, 4975.
Lis, N.; Lamnisos, D.; Bograkou-Tzanetakou, A.; Hadjimbei, E.; Tzanetakou, I.P. Preterm Birth and Its Association with Maternal Diet, and Placental and Neonatal Telomere Length. Nutrients 2023, 15, 4975.
Lis, N.; Lamnisos, D.; Bograkou-Tzanetakou, A.; Hadjimbei, E.; Tzanetakou, I.P. Preterm Birth and Its Association with Maternal Diet, and Placental and Neonatal Telomere Length. Nutrients2023, 15, 4975.
Lis, N.; Lamnisos, D.; Bograkou-Tzanetakou, A.; Hadjimbei, E.; Tzanetakou, I.P. Preterm Birth and Its Association with Maternal Diet, and Placental and Neonatal Telomere Length. Nutrients 2023, 15, 4975.
Abstract
Preterm birth (PTB), a multi-causal syndrome, is one of the global epidemics. Maternal nutrition, but also neonatal and placental telomere length (TL), are among the factors affecting PTB risk. However, the exact relationship between these factors and the PTB outcome, remains obscure. The aim of this review, was to investigate the association between PTB, maternal nutrition and placental-infant TL. Observational studies were sought, with the keywords: maternal nutrition, placenta TL, newborn, TL, and PTB. No study was found that included all keywords simultaneously, and thus, the keywords, were searched in dyads, to reach assumptive conclusions. The findings show that maternal nutrition affects PTB risk, through its influence on maternal TL. On the other hand, maternal TL independently affects PTB risk, and at the same time PTB is a major determinant of offspring TL regulation. The strength of the associations and the extent of the influence from covariates, remains to be elucidated in future research. Furthermore, the question of whether maternal TL, is simply a biomarker of maternal nutritional status and PTB risk, or a causative factor of PTB, to date, remains to be answered.
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
