Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Does Massive Bowel Resection in Newborns Affect Further Immunity in Children?

Katarzyna Sznurkowska
* ,
Anna Borkowska
,
Magdalena Malanowska
ORCID logo ,
Agnieszka Zagierska
,
Maciej Zagierski
,
Maciej Zieliński
ORCID logo ,
Piotr Trzonkowski
ORCID logo ,
Marcin Łosin
,
Agnieszka Szlagatys- Sidorkiewicz
Version 1 : Received: 6 November 2023 / Approved: 7 November 2023 / Online: 7 November 2023 (10:16:37 CET)

A peer-reviewed article of this Preprint also exists.

Sznurkowska, K.; Borkowska, A.; Zagierska, A.; Malanowska, M.; Zieliński, M.; Zagierski, M.; Trzonkowski, P.; Łosin, M.; Szlagatys-Sidorkiewicz, A. Does Massive Bowel Resection in Newborns Affect Further Immunity in Children? Children 2024, 11, 114. Sznurkowska, K.; Borkowska, A.; Zagierska, A.; Malanowska, M.; Zieliński, M.; Zagierski, M.; Trzonkowski, P.; Łosin, M.; Szlagatys-Sidorkiewicz, A. Does Massive Bowel Resection in Newborns Affect Further Immunity in Children? Children 2024, 11, 114.

Abstract

Abstract Background: Massive resection of the small intestine leading to short bowel syndrome (SBS) deprives organism of many immunocompetent cells concentrated in gut associated lymphoid tissue- the largest immune organ in humans. We have aimed to access the influence of bowel resection on adaptive immunity in children, basing on peripheral lymphocyte subsets and serum immunoglobulins. Methods: 15 children, who underwent bowel resection in the first month of life and required further home parenteral nutrition were enrolled into the study.. Based on flow cytometry the following subsets of lymphocytes were evaluated: T, B, NK, CD4+, C8+and activated T cells. Results: Significantly statistical differences were found for the rates of lymphocytes B, T, CD8 + and NK cells. Absolute count of NK cells was lower in SBS group than in the control group. Absolute counts of lymphocytes, lymphocytes B, T, CD4+ and percentages of lymphocytes CD4+, and activated T cells inversely correlated with the time after resection. Conclusions: Children with SBS do not present with clinical signs of immunodeficiency as well as deficits in peripheral lymphocyte subsets and serum immunoglobulins. The tendency of the lymphocyte subpopulations to decrease over time after resection points out the necessity for longer follow- up.

Keywords

short bowel syndrome; lymphocyte subsets; immunoglobulins; children

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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