Encapsulation of the Phage Lytic Protein CHAPSH3b in Non-ionic Surfactant-Based Vesicles

Verdiana Marchianò; Ana Catarina Leal Duarte; Seila Agun; Susana Luque; Ismael Marcet; Lucia Fernandez; Maria Matos; Maria Carmen Blanco; Pilar Garcia; Gemma Gutierrez

doi:10.20944/preprints202311.0397.v1

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preprints.org > chemistry and materials science > biomaterials > doi: 10.20944/preprints202311.0397.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Encapsulation of the Phage Lytic Protein CHAPSH3b in Non-ionic Surfactant-Based Vesicles

Verdiana Marchianò

Ana Catarina Leal Duarte

^* ,

Version 1 : Received: 6 November 2023 / Approved: 7 November 2023 / Online: 7 November 2023 (06:45:46 CET)

How to cite: Marchianò, V.; Duarte, A.C.L.; Agun, S.; Luque, S.; Marcet, I.; Fernandez, L.; Matos, M.; Blanco, M.C.; Garcia, P.; Gutierrez, G. Encapsulation of the Phage Lytic Protein CHAPSH3b in Non-ionic Surfactant-Based Vesicles. Preprints 2023, 2023110397. https://doi.org/10.20944/preprints202311.0397.v1 Marchianò, V.; Duarte, A.C.L.; Agun, S.; Luque, S.; Marcet, I.; Fernandez, L.; Matos, M.; Blanco, M.C.; Garcia, P.; Gutierrez, G. Encapsulation of the Phage Lytic Protein CHAPSH3b in Non-ionic Surfactant-Based Vesicles. Preprints 2023, 2023110397. https://doi.org/10.20944/preprints202311.0397.v1

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MDPI and ACS Style

Marchianò, V.; Duarte, A.C.L.; Agun, S.; Luque, S.; Marcet, I.; Fernandez, L.; Matos, M.; Blanco, M.C.; Garcia, P.; Gutierrez, G. Encapsulation of the Phage Lytic Protein CHAPSH3b in Non-ionic Surfactant-Based Vesicles. Preprints 2023, 2023110397. https://doi.org/10.20944/preprints202311.0397.v1

APA Style

Marchianò, V., Duarte, A.C.L., Agun, S., Luque, S., Marcet, I., Fernandez, L., Matos, M., Blanco, M.C., Garcia, P., & Gutierrez, G. (2023). Encapsulation of the Phage Lytic Protein CHAPSH3b in Non-ionic Surfactant-Based Vesicles. Preprints. https://doi.org/10.20944/preprints202311.0397.v1

Chicago/Turabian Style

Marchianò, V., Pilar Garcia and Gemma Gutierrez. 2023 "Encapsulation of the Phage Lytic Protein CHAPSH3b in Non-ionic Surfactant-Based Vesicles" Preprints. https://doi.org/10.20944/preprints202311.0397.v1

Abstract

Antimicrobial resistance (AMR) has become a worldwide health problem. Consequently, there is a global interest in the study of the antimicrobial activity of natural compounds as an alternative to antibiotics. One of the possibilities studied during the last years is the use of bacteriophages and their derived proteins. More specifically, phage lytic proteins or endolysins are specific enzymes that cause cell lysis and can be easily produced and purified after overexpression in bacteria. However, one of the major disadvantages of these proteins is their sensitivity to some environmental conditions that can reduce their efficiency. The use of vesicles for endolysin encapsulation could help overcome this disadvantage, offering an additional protection to the protein and allowing its controlled release and long-term stability.

Keywords

Antimicrobial activity; vesicles; endolysin; encapsulation; gelatine films

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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