Version 1
: Received: 3 November 2023 / Approved: 3 November 2023 / Online: 6 November 2023 (01:27:27 CET)
How to cite:
Zakaria, Z.Z.; Ahen, Y.; Haj Ahmed, N.; Sokary, S.; Bawadi, H.; Al-Asmakh, M. Exploring Elaeagnus Angustifolia: A Comprehensive Review of its Potential in Cancer Treatment and Management. Preprints2023, 2023110243. https://doi.org/10.20944/preprints202311.0243.v1
Zakaria, Z.Z.; Ahen, Y.; Haj Ahmed, N.; Sokary, S.; Bawadi, H.; Al-Asmakh, M. Exploring Elaeagnus Angustifolia: A Comprehensive Review of its Potential in Cancer Treatment and Management. Preprints 2023, 2023110243. https://doi.org/10.20944/preprints202311.0243.v1
Zakaria, Z.Z.; Ahen, Y.; Haj Ahmed, N.; Sokary, S.; Bawadi, H.; Al-Asmakh, M. Exploring Elaeagnus Angustifolia: A Comprehensive Review of its Potential in Cancer Treatment and Management. Preprints2023, 2023110243. https://doi.org/10.20944/preprints202311.0243.v1
APA Style
Zakaria, Z.Z., Ahen, Y., Haj Ahmed, N., Sokary, S., Bawadi, H., & Al-Asmakh, M. (2023). Exploring Elaeagnus Angustifolia: A Comprehensive Review of its Potential in Cancer Treatment and Management. Preprints. https://doi.org/10.20944/preprints202311.0243.v1
Chicago/Turabian Style
Zakaria, Z.Z., Hiba Bawadi and Maha Al-Asmakh. 2023 "Exploring Elaeagnus Angustifolia: A Comprehensive Review of its Potential in Cancer Treatment and Management" Preprints. https://doi.org/10.20944/preprints202311.0243.v1
Abstract
Cancer is currently the second leading cause of death worldwide, second only to ischemic heart disease, with approximately 8.97 million estimated deaths. However, projections indicate that it is expected to surpass heart disease and become the leading cause of death by 2060. Lung, liver, and stomach cancer are the deadliest malignancies in the general population, while lung and breast cancer predominate as the primary causes of cancer-related death in men and women, respectively. Apart from conventional treatments, there is a growing interest in exploring plant-based drugs for cancer management. Elaeagnus angustifolia, a medicinal plant with a history of traditional use in various cultures for its therapeutic properties, has recently garnered attention as a potential cancer treatment due to its reported anti-cancer effects. This review article aims to comprehensively summarize the current research on Elaeagnus angustifolia and its therapeutic applications in cancer. It delves into in vitro studies investigating the plant's interactions with cancer cells, uncovering mechanisms such as apoptosis induction, cell cycle arrest, and modulation of signalling pathways. In addition to in vitro research, the review evaluates in vivo and preclinical studies assessing the safety and efficacy of Elaeagnus angustifolia in animal models, emphasizing the promising outcomes and underscoring the need for well-designed clinical trials to validate its potential benefits in human cancer patients. The review provides valuable insights into the current research on Elaeagnus angustifolia's role in cancer treatment. It underscores the necessity for further investigations, including clinical trials, to establish its safety, efficacy, and optimal use in cancer management.
Keywords
Elaeagnus angustifolia; Russian Olive; fruit extract; therapeutic; malignancy; cancer
Subject
Medicine and Pharmacology, Complementary and Alternative Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
