Youssef, R.; Maniar, R.; Khan, J.; Mesa, H. Metabolic Interplay in the Tumor Microenvironment: Implications for Immune Function and Anticancer Response. Curr. Issues Mol. Biol.2023, 45, 9753-9767.
Youssef, R.; Maniar, R.; Khan, J.; Mesa, H. Metabolic Interplay in the Tumor Microenvironment: Implications for Immune Function and Anticancer Response. Curr. Issues Mol. Biol. 2023, 45, 9753-9767.
Youssef, R.; Maniar, R.; Khan, J.; Mesa, H. Metabolic Interplay in the Tumor Microenvironment: Implications for Immune Function and Anticancer Response. Curr. Issues Mol. Biol.2023, 45, 9753-9767.
Youssef, R.; Maniar, R.; Khan, J.; Mesa, H. Metabolic Interplay in the Tumor Microenvironment: Implications for Immune Function and Anticancer Response. Curr. Issues Mol. Biol. 2023, 45, 9753-9767.
Abstract
The TME, consisting of immune cells, fibroblasts, vessels, and the extracellular matrix, regulates tumor progression and therapy responses. TME-targeted therapies aim to transform this environment from supporting tumor growth to impeding it and fostering an effective immune response. This review examines the metabolic disparities between immune cells and cancer cells, their impact on immune function and therapeutic targeting, the TME components, and the complex interplay between cancer cells and non-tumoral cells. The success of TME-targeted therapies highlights their potential in achieving better cancer control or even a cure.
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
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