Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Memory Recovery Effect of New Bioactive Innovative Combination in Rats with Experimental Dementia

Lyubka Tancheva
,
Reni Kalfin
* ORCID logo ,
Borislav Minchev
,
Diamara Uzunova
,
Krasimira Tasheva
,
Elina Tsvetanova
,
Almira Georgieva
ORCID logo ,
Albena Alexandrova
ORCID logo ,
Miroslava Stefanova
ORCID logo ,
Ayten Solak
,
Maria Lazarova
ORCID logo ,
Yordan Hodzhev
,
Valentina Grigorova
,
Dobri Yarkov
,
Polina Petkova-Kirova
* ORCID logo
Version 1 : Received: 2 November 2023 / Approved: 3 November 2023 / Online: 3 November 2023 (05:04:23 CET)

A peer-reviewed article of this Preprint also exists.

Tancheva, L.; Kalfin, R.; Minchev, B.; Uzunova, D.; Tasheva, K.; Tsvetanova, E.; Georgieva, A.; Alexandrova, A.; Stefanova, M.; Solak, A.; Lazarova, M.; Hodzhev, Y.; Grigorova, V.; Yarkov, D.; Petkova-Kirova, P. Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia. Antioxidants 2023, 12, 2050. Tancheva, L.; Kalfin, R.; Minchev, B.; Uzunova, D.; Tasheva, K.; Tsvetanova, E.; Georgieva, A.; Alexandrova, A.; Stefanova, M.; Solak, A.; Lazarova, M.; Hodzhev, Y.; Grigorova, V.; Yarkov, D.; Petkova-Kirova, P. Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia. Antioxidants 2023, 12, 2050.

Abstract

Alzheimer’s disease manifests itself as a complex pathological condition with neuroinflammation, oxidative stress and cholinergic dysfunction being a few of the many pathological changes. Due to the complexity of the disease current therapeutic strategies aim at a multitargeted approach often relying on a combination of sub-stances with versatile and complementary effects. In the present study, unique combination of α-lipoic acid, citicoline, extracts of leaves from olive tree and green tea, Vitamin D3, selenium and an immune supporting complex was tested in a scopolamine-induced dementia in rats. Using behavioral and biochemical methods we assessed the effects of this combination on learning and memory, and elucidated the mechanisms under-lying its effects. Our results showed that as compared to the components, experimental combination was most efficient in improving short- and long-term memory assessed by the step-through method as well as spatial memory, assessed by T-maze and Barnes maze underlying decrease in AChE activity and LPO, in-creases in SOD activity in cortex; activities of catalase and GPx, levels of BDNF and pCREB in the hippocam-pus. No significant histopathological changes or blood parameter changes were detected, making the experi-mental combination an effective and safe candidate in a multitargeted treatment of AD.

Keywords

Alzheimer’s disease; α-lipoic acid; citicoline; extract of leaves green tea; extract of leaves olive tree; vitamin D3; selenium; scopolamine

Subject

Public Health and Healthcare, Other

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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