Version 1
: Received: 2 November 2023 / Approved: 3 November 2023 / Online: 3 November 2023 (04:20:57 CET)
How to cite:
Radeke, C.; Wang, Z.; Rabold, F. Oblong True Shape Tablets as an Industrial Scale Digital Twin. Preprints2023, 2023110198. https://doi.org/10.20944/preprints202311.0198.v1
Radeke, C.; Wang, Z.; Rabold, F. Oblong True Shape Tablets as an Industrial Scale Digital Twin. Preprints 2023, 2023110198. https://doi.org/10.20944/preprints202311.0198.v1
Radeke, C.; Wang, Z.; Rabold, F. Oblong True Shape Tablets as an Industrial Scale Digital Twin. Preprints2023, 2023110198. https://doi.org/10.20944/preprints202311.0198.v1
APA Style
Radeke, C., Wang, Z., & Rabold, F. (2023). Oblong True Shape Tablets as an Industrial Scale Digital Twin. Preprints. https://doi.org/10.20944/preprints202311.0198.v1
Chicago/Turabian Style
Radeke, C., Zihan Wang and Frank Rabold. 2023 "Oblong True Shape Tablets as an Industrial Scale Digital Twin" Preprints. https://doi.org/10.20944/preprints202311.0198.v1
Abstract
Tablets are the most used solid dosage form in medical treatments. The realistic modeling 1 of such specific object shapes in computer simulations has been demonstrated already by the author 2 for bi-convex round tablets but needs to be extended for a wider range of tablet shapes. Moreover, 3 the number of tablets must be large enough to simulate industrial drum coaters, which are typically 4 used for film coating processes. Whilst this long lasting process where tablets flow continuously, 5 tablets are loaded by frequent changes of individual contacts. Using a tailored simulation tool named 6 pharmAssist , written for GPUs (modern massively parallel processors in graphics cards and HPC 7 accelerators), we implemented the widely used oblong tablet shape. We are able to simulate flows 8 involving industrial scale number of such tablets. Data mining allows for statistical analyzis of 9 pair-wise contacts of different geometric features. Our simulation results serves as an observation 10 space, which cannot be addressed by experimental analyzis and will help to avoid degradation of 11 tablets like chipping or other defect phenomena. This paper reflects current development work in 12 order to extend the DEM with a new shape class, which comprises the modelling of compacted or 13 extruded objects, which have a smooth exterior, a flat band and sharp contour edges
Keywords
DEM; drum coating; mixing; tablet shape; digital twin; GPU
Subject
Engineering, Industrial and Manufacturing Engineering
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
