Review
Version 1
Preserved in Portico This version is not peer-reviewed
Structure Overview of Herpesvirus Tegument Proteins
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Version 1
: Received: 1 November 2023 / Approved: 2 November 2023 / Online: 2 November 2023 (10:13:22 CET)
How to cite: He, H.; Gao, S. Structure Overview of Herpesvirus Tegument Proteins. Preprints 2023, 2023110147. https://doi.org/10.20944/preprints202311.0147.v1 He, H.; Gao, S. Structure Overview of Herpesvirus Tegument Proteins. Preprints 2023, 2023110147. https://doi.org/10.20944/preprints202311.0147.v1
Abstract
Herpesviridae is a family of enveloped double-stranded DNA viruses that cause a wide range of diseases in hosts. Among the various components of herpesvirus particles, tegument proteins residing between the envelop and nucleocapsid play crucial roles in viral replication, immune evasion, and modulation of host cellular pathways. Understanding the three-dimensional structure of herpesvirus tegument proteins help to reveal the molecular mechanism underlying the crosstalk with other viral and cellular components, and thus is crucial for the investigation of their biological and pathological functions. In this review, we summarize the current knowledge of the structural features of herpesvirus tegument proteins, highlighting the structure-based functional implications, including the potential as targets for antiviral drug development.
Keywords
Herpesviruses; Tegument proteins; Structure; Viral pathogenesis
Subject
Biology and Life Sciences, Virology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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