Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

From Chronodisruption to Sarcopenia: The Therapeutic Potential of Melatonin

José Fernández-Martínez
† ORCID logo ,
Yolanda Ramírez-Casas
† ORCID logo ,
Yang Yang
,
Paula Aranda-Martínez
ORCID logo ,
Laura Martínez-Ruiz
,
Germaine Escames
ORCID logo ,
And Darío Acuña-Castroviejo
* ORCID logo
†
These authors contributed equally to this work.
Version 1 : Received: 31 October 2023 / Approved: 31 October 2023 / Online: 1 November 2023 (03:02:46 CET)

A peer-reviewed article of this Preprint also exists.

Fernández-Martínez, J.; Ramírez-Casas, Y.; Yang, Y.; Aranda-Martínez, P.; Martínez-Ruiz, L.; Escames, G.; Acuña-Castroviejo, D. From Chronodisruption to Sarcopenia: The Therapeutic Potential of Melatonin. Biomolecules 2023, 13, 1779. Fernández-Martínez, J.; Ramírez-Casas, Y.; Yang, Y.; Aranda-Martínez, P.; Martínez-Ruiz, L.; Escames, G.; Acuña-Castroviejo, D. From Chronodisruption to Sarcopenia: The Therapeutic Potential of Melatonin. Biomolecules 2023, 13, 1779.

Abstract

Sarcopenia is an age-related condition that involves a progressive decline in muscle mass and function, leading to increased risks of falls, frailty, and mortality. Although the exact mechanisms are not fully understood, aging-related processes like inflammation, oxidative stress, reduced mitochondrial capacity, and cell apoptosis contribute to this decline. Disruption of the circadian system with age may initiate these pathways in skeletal muscle, preceding the onset of sarcopenia. At present, there is no pharmacological treatment for sarcopenia, only resistance exercise and proper nutrition may delay its onset. Melatonin, derived from tryptophan, emerges as an exceptional candidate for treating sarcopenia due to its chronobiotic, antioxidant, and anti-inflammatory properties. Its impact on mitochondria, organelle where it is synthesized and crucial in aging skeletal muscle, further highlights its potential. In this review, we discuss the influence of clock genes in muscular aging, with special reference to peripheral clock genes in the skeletal muscle, as well as their relationship with melatonin, which is proposed as a potential therapy against sarcopenia.

Keywords

aging; chronodisruption; clock genes; Bmal1; inflammaging; oxidative stress; mitochondria; skeletal muscle; sarcopenia; melatonin

Subject

Biology and Life Sciences, Aging

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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