Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Probiotics in Post-Operative Pain Management

Barbara Fyntanidou
,
Aikaterini Amaniti
,
Eleftheria Soulioti
,
Sofia-Chrysovalantou Zagalioti
ORCID logo ,
Sofia Gkarmiri
,
Angeliki Chorti
,
Lamprini Loukipoudi
,
Aris Ioannidis
,
Ioannis Dalakakis
,
Alexandra-Eleftheria Menni
ORCID logo ,
Anne D. Shrewsbury
,
Katerina Kotzampassi
* ORCID logo
Version 1 : Received: 30 October 2023 / Approved: 31 October 2023 / Online: 31 October 2023 (10:50:24 CET)

A peer-reviewed article of this Preprint also exists.

Fyntanidou, B.; Amaniti, A.; Soulioti, E.; Zagalioti, S.-C.; Gkarmiri, S.; Chorti, A.; Loukipoudi, L.; Ioannidis, A.; Dalakakis, I.; Menni, A.-E.; Shrewsbury, A.D.; Kotzampassi, K. Probiotics in Postoperative Pain Management. J. Pers. Med. 2023, 13, 1645. Fyntanidou, B.; Amaniti, A.; Soulioti, E.; Zagalioti, S.-C.; Gkarmiri, S.; Chorti, A.; Loukipoudi, L.; Ioannidis, A.; Dalakakis, I.; Menni, A.-E.; Shrewsbury, A.D.; Kotzampassi, K. Probiotics in Postoperative Pain Management. J. Pers. Med. 2023, 13, 1645.

Abstract

Post-operative pain is the unpleasant sensory and emotional experience after surgery, its origin being both the inflammatory reaction induced by the surgical trauma on the abdominal wall, and the splanchnic pain, induced by the activation of nociceptors of the viscera, which are highly sensi-tive to distension, ischemia and inflammation. Nowadays, it is well recognized that there is a close relationship between the gut microbiome and pain perception, and that microbiome is highly af-fected by both anaesthesia and surgical manipulation. Thus, efforts to restore the disturbed micro-biome by supplementation with beneficial bacteria, namely probiotics, seems to be effective. In this article the knowledge gained mainly from experimental research on this topic is analyzed, the con-cluding message being that each probiotic strain works in its own way towards pain relief.

Keywords

probiotics; post-operative pain; microbiome; visceral pain; abdominal wall pain; inflammation; opioids; cannabinoids

Subject

Medicine and Pharmacology, Anesthesiology and Pain Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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