Wasim, S.; Park, J.; Nam, S.; Kim, J. Review of Current Treatment Intensification Strategies for Prostate Cancer Patients. Cancers2023, 15, 5615.
Wasim, S.; Park, J.; Nam, S.; Kim, J. Review of Current Treatment Intensification Strategies for Prostate Cancer Patients. Cancers 2023, 15, 5615.
Wasim, S.; Park, J.; Nam, S.; Kim, J. Review of Current Treatment Intensification Strategies for Prostate Cancer Patients. Cancers2023, 15, 5615.
Wasim, S.; Park, J.; Nam, S.; Kim, J. Review of Current Treatment Intensification Strategies for Prostate Cancer Patients. Cancers 2023, 15, 5615.
Abstract
Prostate cancer (PCa) used to be one of the most common nondermatologic cancers in men that can be treated only with surgery. However, a revolutionary breakthrough came in the 1980s with the introduction of long-acting luteinizing hormone-releasing hormone (LHRH) agonists for the cu-rative treatment of PCa. This paradigm shift contributed to the combined use of androgen depri-vation therapy (ADT), chemotherapy, and radiotherapy for the treatment. The latest data high-light the use of treatment intensification (TI), i.e., combined use of radiotherapy (RT) and hormo-nal or drug treatments, for localized or locally advanced PCa. Indeed, the results of combined modality treatments have shown a reduction in disease-specific mortality and improved overall survival. Although TI seems promising, more research studies are warranted to confirm its effi-cacy. This review summarizes the latest available outcome results of pivotal trials and clinical studies on the efficacy of TI.
Keywords
Radiotherapy/Radiation therapy; ADT; LHRH agonist; Treatment intensification; Prostate cancer
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
