Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Designing and Manufacturing of Biocompatible Hydroxyap-atite and Sodium Trisilicate Scaffolds by Ordinary Commercial Microwave Oven

Giorgio Luciano
* ORCID logo ,
Maurizio Vignolo
,
Denise Galante
,
Cristina D'Arrigo
ORCID logo ,
Franco Furlani
,
Monica Montesi
,
Silvia Panseri
Version 1 : Received: 30 October 2023 / Approved: 30 October 2023 / Online: 30 October 2023 (14:44:12 CET)

A peer-reviewed article of this Preprint also exists.

Luciano, G.; Vignolo, M.; Galante, D.; D’Arrigo, C.; Furlani, F.; Montesi, M.; Panseri, S. Designing and Manufacturing of Biocompatible Hydroxyapatite and Sodium Trisilicate Scaffolds by Ordinary Domestic Microwave Oven. Compounds 2024, 4, 106-118. Luciano, G.; Vignolo, M.; Galante, D.; D’Arrigo, C.; Furlani, F.; Montesi, M.; Panseri, S. Designing and Manufacturing of Biocompatible Hydroxyapatite and Sodium Trisilicate Scaffolds by Ordinary Domestic Microwave Oven. Compounds 2024, 4, 106-118.

Abstract

In this work we present a versatile, rapid, and low-cost manufacturing technique to develop bioceramic scaffolds that could enhance bone tissue regeneration via microwave preparation using a commercial microwave oven. The scaffolds were prepared combining hydroxyapatite and water glass (sodium trisilicate solution), foamed by using a microwaves oven and then characterized by means of SEM-EDS, mechanical properties, infrared spectroscopy (ATR-FTIR), density and stability test in water. Furthermore, in vitro tests were performed to verify the affinity of osteoclast cells versus the so prepared scaffold. The morphology of the samples showed interconnected pores suitable for promoting tissue regeneration and vascularization while specific mechanical properties were preserved. The physicochemical characterization and the in vitro tests presented promising results for bone regenerative applications.

Keywords

Microwave; Foaming Bone Scaffold; Sodium Trisilicate; Hydroxyapatite; In Vitro Tests

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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