Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Analysis of Antibacterial Efficacy and Unique Chemical Compositions Generated from Plasma Activated Water.

Hyun Jin Kim
ORCID logo ,
Hyun A Shin
,
Woo Kyung Chung
,
Ae Son Om
,
Areum Jeon
,
Eun Kyung Kang
,
Wen An
,
Ju Seop Kang
* ORCID logo
Version 1 : Received: 26 October 2023 / Approved: 26 October 2023 / Online: 27 October 2023 (03:50:40 CEST)

A peer-reviewed article of this Preprint also exists.

Kim, H.-J.; Shin, H.-A.; Chung, W.-K.; Om, A.-S.; Jeon, A.; Kang, E.-K.; An, W.; Kang, J.-S. Analyses of the Chemical Composition of Plasma-Activated Water and Its Potential Applications for Vaginal Health. Biomedicines 2023, 11, 3121. Kim, H.-J.; Shin, H.-A.; Chung, W.-K.; Om, A.-S.; Jeon, A.; Kang, E.-K.; An, W.; Kang, J.-S. Analyses of the Chemical Composition of Plasma-Activated Water and Its Potential Applications for Vaginal Health. Biomedicines 2023, 11, 3121.

Abstract

This study aimed to elucidate the antibacterial efficacy and unique chemical compositions generated from plasma-activated water (PAW) when utilized a novel vaginal cleansing device. We conducted an analysis of antibacterial activity against probiotics and several chemical compositions including ions under various operational parameters of PAW, including electrical power (12 and 24 V), treatment duration (1, 10, and 20 min), and stay duration (immediate, 30 and 60 min). Our findings revealed that as treatment duration increased, hypochlorous acid (HOCl), Ca2+, and Mg2+ concentrations increased and Cl−concentrations decreased. Higher electrical power and longer treatment duration resulted in increased HOCl levels, which acts to prevent the growth of general microorganisms. Notably, PAW exhibited no antibacterial effects against a type of probiotic, Lactobacillus reuteri that produces lactic acid for vaginal health. This result demonstrated the ability of the vaginal cleaning device to generate ions, primarily HOCl and some cations (Ca2+ and Mg2+), thereby providing vaginal mucosa protecting and cleansing effects with the vaginal environment.

Keywords

plasma-activated water (PAW); hypochlorous acid (HOCl); probiotics(Lactobacillus reuteri ); mucosa protection; vaginal cleansing effect.

Subject

Medicine and Pharmacology, Other

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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