Gupta, M. N., & Uversky, V. N. (2023). Biological importance of arginine: A comprehensive review of the roles in structure, disorder, and functionality of peptides and proteins. International Journal of Biological Macromolecules, 128646.
Gupta, M. N., & Uversky, V. N. (2023). Biological importance of arginine: A comprehensive review of the roles in structure, disorder, and functionality of peptides and proteins. International Journal of Biological Macromolecules, 128646.
Gupta, M. N., & Uversky, V. N. (2023). Biological importance of arginine: A comprehensive review of the roles in structure, disorder, and functionality of peptides and proteins. International Journal of Biological Macromolecules, 128646.
Gupta, M. N., & Uversky, V. N. (2023). Biological importance of arginine: A comprehensive review of the roles in structure, disorder, and functionality of peptides and proteins. International Journal of Biological Macromolecules, 128646.
Abstract
Arginine shows Jekyll and Hyde behavior in several respects. It participates in protein folding via ionic and H-bonds and cation-pi interactions; the charge and hydrophobicity of its side chain makes it a disorder-promoting amino acid. Its methylation in histones; RNA binding proteins; chaperones regulates several cellular processes. The arginine-centric modifications are important in oncogenesis and as biomarkers in several cardiovascular diseases. The cross-links involving arginine in collagen and cornea are involved in pathogenesis of tissues but have also been useful in tissue engineering and wound-dressing materials. Arginine is a part of active site of several enzymes such as GTPases, peroxidases, and sulfotransferases. Its metabolic importance is obvious as it is involved in production of urea, NO, ornithine and citrulline. It can form unusual functional structures such as molecular tweezers in vitro and sprockets which engage DNA chains as part of histones in vivo. It has been used in design of cell-penetrating peptides as drugs. Arginine has been used as an excipient in both solid and injectable drug formulations; its role in suppressing opalescence due to liquid-liquid phase separation is particularly very promising. It has been known as a suppressor of protein aggregation during protein refolding. It has proved its usefulness in protein bioseparation processes like ion-exchange, hydrophobic and affinity chromatographies. Arginine is an amino acid, whose importance in biological sciences and biotechnology continues to grow in diverse ways.
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