Roy, R.; Singh, S.K.; Ahmad, N.; Misra, S. Challenges and Advancements in High-Throughput Screening Strategies for Cancer Therapeutics. Global Translational Medicine 2024, 3, 2448, doi:10.36922/gtm.2448.
Roy, R.; Singh, S.K.; Ahmad, N.; Misra, S. Challenges and Advancements in High-Throughput Screening Strategies for Cancer Therapeutics. Global Translational Medicine 2024, 3, 2448, doi:10.36922/gtm.2448.
Roy, R.; Singh, S.K.; Ahmad, N.; Misra, S. Challenges and Advancements in High-Throughput Screening Strategies for Cancer Therapeutics. Global Translational Medicine 2024, 3, 2448, doi:10.36922/gtm.2448.
Roy, R.; Singh, S.K.; Ahmad, N.; Misra, S. Challenges and Advancements in High-Throughput Screening Strategies for Cancer Therapeutics. Global Translational Medicine 2024, 3, 2448, doi:10.36922/gtm.2448.
Abstract
Drug discovery utilizes high-throughput screening (HTS) methods applying target and cell-based assays. This review discusses the challenges and benefits associated with these assays in HTS. Discussed the strategies that can be applied for the development of screening assays through primary and secondary screens for target identification. Further discussion on identify-ing the most efficacious drugs following these approaches in cancer. Even though various drugs have been identified to treat cancer, there is high demand of more relevant phenotypic assays to produce desired diseased phenotype to only highlighting the specific targets instead of off-targets. Hopefully, the new developing strategies could provide innovative drugs to treat cancer patients to reduce mortality rate.
Keywords
target based screening; phenotypic based screening; targets; transcriptional reprogramming, highthroughput screening, cancer therapeutics
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
