Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Ketamine, an Old–New Drug: Uses and Abuses

Katarina Savić Vujović
* ,
Ana Jotić
ORCID logo ,
Branislava Medić
ORCID logo ,
Dragana Srebro
ORCID logo ,
Aleksandar Vujović
,
Janko Žujović
,
Ana Opanković
,
Sonja Vučković
Version 1 : Received: 25 October 2023 / Approved: 26 October 2023 / Online: 26 October 2023 (11:03:22 CEST)

A peer-reviewed article of this Preprint also exists.

Savić Vujović, K.; Jotić, A.; Medić, B.; Srebro, D.; Vujović, A.; Žujović, J.; Opanković, A.; Vučković, S. Ketamine, an Old–New Drug: Uses and Abuses. Pharmaceuticals 2024, 17, 16. Savić Vujović, K.; Jotić, A.; Medić, B.; Srebro, D.; Vujović, A.; Žujović, J.; Opanković, A.; Vučković, S. Ketamine, an Old–New Drug: Uses and Abuses. Pharmaceuticals 2024, 17, 16.

Abstract

Ketamine as an old - new drug has variety of clinical implications. In the last 30 years, ketamine has become popular for acute use in humans. Ketamine at standard doses is principally utilized for the induction and maintenance in surgical procedures. Beside its use in anesthesia and analgesia, recently studies had shown that ketamine find the place in the treatment of asthma, epilepsy, depression, bipolar affective disorders, alcohol and heroin addiction. Its mechanism of action is complex, but it mostly acts as a noncompetitive antagonist at the N-methyl-D-aspartate (NMDA) receptor. Ketamine is generally considered relatively secure and does not result in serious adverse effects when used at low doses and for short periods- Also, ketamine is known as a powerful psychostimulant. During the past decade, ketamine has been one of the commonly abused drug.

Keywords

ketamine; analgesia; anesthesia; clinical implications; abuse

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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