Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Hydration for Adult Patients with Nephrolithiasis: Specificities and Current Recommendations

Version 1 : Received: 25 October 2023 / Approved: 25 October 2023 / Online: 26 October 2023 (07:40:26 CEST)

A peer-reviewed article of this Preprint also exists.

Courbebaisse, M.; Travers, S.; Bouderlique, E.; Michon-Colin, A.; Daudon, M.; De Mul, A.; Poli, L.; Baron, S.; Prot-Bertoye, C. Hydration for Adult Patients with Nephrolithiasis: Specificities and Current Recommendations. Nutrients 2023, 15, 4885. Courbebaisse, M.; Travers, S.; Bouderlique, E.; Michon-Colin, A.; Daudon, M.; De Mul, A.; Poli, L.; Baron, S.; Prot-Bertoye, C. Hydration for Adult Patients with Nephrolithiasis: Specificities and Current Recommendations. Nutrients 2023, 15, 4885.

Abstract

Nephrolithiasis affects around 10% of the population and is frequently associated with impaired dietary factors. The first one is insufficient fluid intake inducing reduced urine volume, urine supersaturation, and subsequently urinary lithiasis. Kidneys regulate 24-hour urine volume, which, under physiological conditions, approximately reflect daily fluid intake. Increasing fluid intake has a preventive effect on the risk of developing a first kidney stone (primary prevention) but also decreases the risk of stone recurrence (secondary prevention). Current guidelines recommend increasing fluid intake at least at 2.5L /day to prevent stone formation, and even at 3.5-4L in some severe forms of nephrolithiasis (primary or enteric hyperoxaluria or cystinuria). Fluid intake must also be balanced between day and night, to avoid urinary supersaturation during the night. Patients should be informed and supported in this difficult process of increasing urine dilution, with practical ways and daily routines to increase their fluid intake. The liquid of choice is water, which should be chosen depending on its composition (such as calcium, bicarbonate or magnesium content). Finally, some additional advices have to be given to avoid some beverages such as those containing fructose or phosphoric acid, which are susceptible to increase the risk of nephrolithiasis.

Keywords

Nephrolithiasis; Hydration; Water; Prevention

Subject

Medicine and Pharmacology, Dietetics and Nutrition

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