Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Hematopoietic Cell Transplantation Trends and Outcomes in Canada: A Registry-based Cohort Study

Matthew D. Seftel
* ORCID logo ,
Ivan Pasic
,
Gaganvir Parmar
,
Oliver Bucher
ORCID logo ,
David S. Allan
,
Sita Bhella
,
Kevin Anthony Hay
,
Olaweseun Ikuomola
,
Grace Musto
,
Anca Prica
,
Erin Richardson
,
Tony H Truong
,
Kristjan Paulson
Version 1 : Received: 24 October 2023 / Approved: 24 October 2023 / Online: 25 October 2023 (11:50:41 CEST)

A peer-reviewed article of this Preprint also exists.

Seftel, M.D.; Pasic, I.; Parmar, G.; Bucher, O.; Allan, D.S.; Bhella, S.; Hay, K.A.; Ikuomola, O.; Musto, G.; Prica, A.; Richardson, E.; Truong, T.H.; Paulson, K. Hematopoietic Cell Transplantation Trends and Outcomes in Canada: A Registry-Based Cohort Study. Curr. Oncol. 2023, 30, 9953-9967. Seftel, M.D.; Pasic, I.; Parmar, G.; Bucher, O.; Allan, D.S.; Bhella, S.; Hay, K.A.; Ikuomola, O.; Musto, G.; Prica, A.; Richardson, E.; Truong, T.H.; Paulson, K. Hematopoietic Cell Transplantation Trends and Outcomes in Canada: A Registry-Based Cohort Study. Curr. Oncol. 2023, 30, 9953-9967.

Abstract

Background: Hematopoietic cell transplantation (HCT) is an established therapy for hematologic malignancies and serious non-malignant blood disorders. Despite its curative potential, HCT is associated with substantial toxicity and health resource utilization. Effective delivery of HCT requires complex hospital-based care, which limits the number of HCT centers in Canada. In Canada, the quantity, indications, temporal trends, and outcomes of patients receiving HCT are not known. Methods: A retrospective cohort study of first transplants reported to the Cell Therapy Transplant Canada (CTTC) registry between 2000 and 2019. We determined overall survival (OS) and non-relapse mortality (NRM), categorizing the cohort into early (2000-2009) and later (2010-2019) eras to investigate temporal changes. Results: Of 18,046 transplants, 10,475 were allogeneic and 7,571 were autologous. Comparing the two eras, allogeneic transplants increased in number by 22.3%, with greater use of matched unrelated donors in the later era. Autologous transplants increased by 10.9%. Temporal improvements in NRM were observed in children and adults. OS improved in pediatric patients and in adults receiving autologous HCT. In adults receiving allogeneic HCT, OS was stable despite the substantially older age of patients in the later era. Interpretation: HCT is an increasingly frequent procedure in Canada which has expanded to serve older adults. Noted improvements in NRM and OS reflect progress in patient and donor selection, preparation for transplant, and post- transplant supportive care. In allogeneic HCT, unrelated donors have become the most frequent donor source, highlighting the importance of continued growth of volunteer donor registries. These results serve as a baseline measure for quality improvement and health services planning in Canada.

Keywords

hematopoietic cell transplant; cellular therapy; health outcomes

Subject

Medicine and Pharmacology, Hematology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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