Version 1
: Received: 23 October 2023 / Approved: 24 October 2023 / Online: 25 October 2023 (12:11:05 CEST)
How to cite:
Haddad, F.; Dokmak, G.; Kanwal, S.; Karaman, R. A Comprehensive Review on Therapeutic Potential of Nanobodies. Preprints2023, 2023101583. https://doi.org/10.20944/preprints202310.1583.v1
Haddad, F.; Dokmak, G.; Kanwal, S.; Karaman, R. A Comprehensive Review on Therapeutic Potential of Nanobodies. Preprints 2023, 2023101583. https://doi.org/10.20944/preprints202310.1583.v1
Haddad, F.; Dokmak, G.; Kanwal, S.; Karaman, R. A Comprehensive Review on Therapeutic Potential of Nanobodies. Preprints2023, 2023101583. https://doi.org/10.20944/preprints202310.1583.v1
APA Style
Haddad, F., Dokmak, G., Kanwal, S., & Karaman, R. (2023). A Comprehensive Review on Therapeutic Potential of Nanobodies. Preprints. https://doi.org/10.20944/preprints202310.1583.v1
Chicago/Turabian Style
Haddad, F., Shahla Kanwal and Rafik Karaman. 2023 "A Comprehensive Review on Therapeutic Potential of Nanobodies" Preprints. https://doi.org/10.20944/preprints202310.1583.v1
Abstract
Recently, nanobodies have taken center stage in research on drug discovery and development. Several therapeutic possibilities using nanobodies are presently undergoing clinical trials and waiting for FDA approval. The goal of this study was to emphasize the potential of nanobodies as therapeutic agents by concentrating on the most recent published studies that examined their properties, manufacturing, and possible applications. This article demonstrates that the unique properties of nanobodies in comparison to conventional antibodies, which are based on their small size and offer a number of benefits, make them seem to have a promising future. These advantages include the ability to access complex or hidden target sites that may be elusive to their larger antibody counterparts, and increased resilience against extreme conditions like tempera-ture changes and pH variations. As a result, nanobodies seem to have a bright future as adaptable tools for imaging in cancer and non-malignant diseases, as well as for in vitro and in vivo diagnostic and therapeutic potential for a variety of conditions, including oncology, infectious, metabolic, neurological, and other conditions like ophthalmologic, immune-mediated, and genetic disorders. More research is required to determine their effectiveness and safety in clinical applications. The current analysis offers a thorough overview of the therapeutic uses for nanobody products that are either on the market or undergoing clinical trials.
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
