Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Can Peri-Surgical Electroacupuncture Relieve Immunity Suppression? A Pilot Study in Dogs

Vanessa Rabbogliatti
ORCID logo ,
Federica Alessandra Brioschi
,
Alessandro Pecile
* ORCID logo ,
Valerio Bronzo
ORCID logo ,
Valeria Martini
ORCID logo ,
Paola Dall' Ara
ORCID logo ,
Giuliano Ravasio
ORCID logo ,
Debora Groppetti
ORCID logo
Version 1 : Received: 23 October 2023 / Approved: 24 October 2023 / Online: 25 October 2023 (08:17:57 CEST)

How to cite: Rabbogliatti, V.; Brioschi, F.A.; Pecile, A.; Bronzo, V.; Martini, V.; Dall' Ara, P.; Ravasio, G.; Groppetti, D. Can Peri-Surgical Electroacupuncture Relieve Immunity Suppression? A Pilot Study in Dogs. Preprints 2023, 2023101547. https://doi.org/10.20944/preprints202310.1547.v1 Rabbogliatti, V.; Brioschi, F.A.; Pecile, A.; Bronzo, V.; Martini, V.; Dall' Ara, P.; Ravasio, G.; Groppetti, D. Can Peri-Surgical Electroacupuncture Relieve Immunity Suppression? A Pilot Study in Dogs. Preprints 2023, 2023101547. https://doi.org/10.20944/preprints202310.1547.v1

Abstract

General anesthesia and surgical stress can suppress the immunological response by acting both directly on the immune system and indirectly on the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Disturbance of the immune system during the perioperative period can lead to complications such as wound-healing disorders and infections up to sepsis. Effective-ness of acupuncture in regulating the immune function by increasing leukocyte numbers and in-hibiting inflammatory response has been proven. The aim of this study was to explore the impact of electroacupuncture (EAP) on the dynamic bal-ance of the immune system and immune cell populations in dogs undergoing surgery. For this purpose, twelve healthy bitches scheduled for elective ovariectomy were divided into two groups according to whether (EAP, n=6) or not (CTR, n=6) a peri-operative electroacupuncture treatment was performed. Levels of leukocytes (neutrophils, monocytes, T- and B-cells) and immunoglobu-lins M (IgM) and A (IgA) were measured in blood samples collected before (T0), 1 hour (T1) and 2.5 hours (T2) after anesthesia induction. Leukocytes count decreased from T0 to T1 in both groups and restored within 1.5 hours in EAP group whereas remained significantly lower in CTR group (P<0.02). In particular, neutrophils and monocytes increased in dogs receiving EAP (P<0.01) while T-cells decreased in CTR group (P<0.04) at T2. B-cells and cytotoxic T-cells de-creased in EAP dogs (P<0.04) at T2. No differences in helper T-cells, IgM and IgA levels were recorded between groups and over time. Our results suggest a modulatory effect of EAP on the immune system which is early expressed on neutrophils, monocytes and T-cells.

Keywords

immunoglobulins; leukocytes; lymphocytes

Subject

Biology and Life Sciences, Animal Science, Veterinary Science and Zoology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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