Version 1
: Received: 23 October 2023 / Approved: 23 October 2023 / Online: 23 October 2023 (08:47:58 CEST)
Version 2
: Received: 13 November 2023 / Approved: 13 November 2023 / Online: 13 November 2023 (10:39:49 CET)
How to cite:
Zhang, Y. Cellular Response to an Act of Surviving Drives Tumor Evolution and Tumor Heterogeneity. Preprints2023, 2023101417. https://doi.org/10.20944/preprints202310.1417.v2
Zhang, Y. Cellular Response to an Act of Surviving Drives Tumor Evolution and Tumor Heterogeneity. Preprints 2023, 2023101417. https://doi.org/10.20944/preprints202310.1417.v2
Zhang, Y. Cellular Response to an Act of Surviving Drives Tumor Evolution and Tumor Heterogeneity. Preprints2023, 2023101417. https://doi.org/10.20944/preprints202310.1417.v2
APA Style
Zhang, Y. (2023). Cellular Response to an Act of Surviving Drives Tumor Evolution and Tumor Heterogeneity. Preprints. https://doi.org/10.20944/preprints202310.1417.v2
Chicago/Turabian Style
Zhang, Y. 2023 "Cellular Response to an Act of Surviving Drives Tumor Evolution and Tumor Heterogeneity" Preprints. https://doi.org/10.20944/preprints202310.1417.v2
Abstract
Tumor heterogeneity is a major obstacle to achieving consistent outcomes in cancer therapy. We offer a novel perspective on tumor heterogeneity, informed by an advanced understanding of tumor evolution. We understand any cells, or any organism, will inherently respond with specific capacities when faced with adversity. Our concepts, which extend beyond canonical views, posit that tumor evolution is driven by cellular responses to survival challenges. The disease is driven by a rudimentary action taken by any organism when confronted with adversity - a cellular response to generate specific capacities to overcome the threat - the responses that utilize advantageous genetic mutations and other cellular contents to attain these capacities and further drive the disease. The disease is initiated by a cellular response to survival challenges and the ongoing development of hallmark cancer capabilities, as cells endeavor to obtain a competitive advantage, results in increased molecular disarray, observed as tumor heterogeneity. When the evolutionary drive for survival is impeded by therapeutic inhibition of critical genes, cell death occurs, a phenomenon termed oncogene addiction. Drawing from the same idea that cells responding to survival challenges, we recognize the increasing primitiveness of cancer during its progress stems from the innate cellular response to the demand for regeneration under sustained cellular damage. This necessitates a regression to a more primitive state purposed to renew progeny, unleashing a hitherto undiscerned cellular capacity. Taken together, the ideas explored herein pave the way for novel cancer therapies and the betterment of human health.
Keywords
tumor heterogeneity; cancer progression; oncogene addiction; cancer stem cell
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Helen Zhang
Commenter's Conflict of Interests: Author