Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Positive Assessment of an Autogenous Vaccine Against Pathogenic Escherichia coli in Broiler Breeders and their Progeny in Morocco

Lhoussaine Oubouyahia
* ORCID logo ,
Amal Essalah-Bennani
,
Ouafaa Fassi Fihri
,
Eric Badin
,
Hanan Balil
,
Eric Thibault
,
Hubert Gantelet
,
Saâdia Nassik
Version 1 : Received: 21 October 2023 / Approved: 23 October 2023 / Online: 23 October 2023 (11:00:25 CEST)

How to cite: Oubouyahia, L.; Essalah-Bennani, A.; Fassi Fihri, O.; Badin, E.; Balil, H.; Thibault, E.; Gantelet, H.; Nassik, S. Positive Assessment of an Autogenous Vaccine Against Pathogenic Escherichia coli in Broiler Breeders and their Progeny in Morocco. Preprints 2023, 2023101396. https://doi.org/10.20944/preprints202310.1396.v1 Oubouyahia, L.; Essalah-Bennani, A.; Fassi Fihri, O.; Badin, E.; Balil, H.; Thibault, E.; Gantelet, H.; Nassik, S. Positive Assessment of an Autogenous Vaccine Against Pathogenic Escherichia coli in Broiler Breeders and their Progeny in Morocco. Preprints 2023, 2023101396. https://doi.org/10.20944/preprints202310.1396.v1

Abstract

Excessive use of antibiotics to control colibacillosis on poultry farms in Morocco contributes to the development of multiresistant avian pathogenic E. coli. Autogenous vaccines are an alternative to antibiotic usage; the main goal of this study was to assess the efficacy of this approach to control recurrent outbreaks of colibacillosis in a large broiler production flow. A tetravalent autogenous vaccine (serotypes O78, O88, O91, and O185) was produced from E. coli strains isolated from clinical lesions in breeding hens and used on two farms (65,000 breeding hens in total). On each farm, contemporaneous groups were included: groups vaccinated twice (12 and 18 weeks of age) and unvaccinated control groups. The performances of these flocks, as well as the performances of broilers hatched from these breeders (12 farms, over 600,000 broilers in total), were recorded. A significant reduction in lesion scores, mortality rate and a significant increase in the number of saleable day-old chicks were observed among vaccinated hens. In broilers, body weight at slaughter, lesion scores, food conversion ratio, mortality and condemnation rates were significantly improved. This is the first field observation of a lasting effect of breeder hens immunization with an autogenous vaccine against E. coli on their offspring.

Keywords

APEC; colibacillosis; antimicrobial resistance; autogenous vaccine; poultry integration; Morocco

Subject

Biology and Life Sciences, Animal Science, Veterinary Science and Zoology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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