Risk Awareness as a Key Determinant of Early Vaccine Uptake in the Mpox Vaccination Campaign in an Italian Region: A Cross-Sectional Analysis

Giulia Del Duca; Alessandro Tavelli; Ilaria Mastrorosa; Camilla Aguglia; Simone Lanini; Anna Clelia Brita; Roberta Gagliardini; Serena Vita; Alessandra Vergori; Jessica Paulicelli; Giorgia Natalini; Angela D'Urso; Pierluca Piselli; Paola Gallì; Vanessa Mondillo; Claudio Mastroianni; Enrica Tamburrini; Loredana Sarmati; Cristof Stingone; Miriam Lichtner; Emanuele Nicastri; Massimo Farinella; Filippo Leserri; Andrea Siddu; Francesco Maggi; Antonella D'Arminio Monforte; Francesco Vairo; Alessandra Barca; Francesco Vaia; Enrico Girardi; Valentina Mazzotta; Andrea Antinori

doi:10.20944/preprints202310.1395.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 20 October 2023 / Approved: 23 October 2023 / Online: 24 October 2023 (07:56:10 CEST)

Background: we aim to investigate attitudes toward vaccination, by analyzing empirical factors associated with vaccine acceptance in the Lazio region mpox vaccination (MpoxVax) campaign in Italy. Methods: all subjects who accessed to MpoxVax and signed the informed consent were prospectively enrolled in the MPOX-VAC Study and were asked to fill out an anonymous survey. Two endpoints were selected: ‘delayed acceptance’ and ‘early acceptance’, defined as access for vaccination >60 and ≤30 days from the vaccination campaign starting (VCS), respectively. Results: over the study period 1717 individuals underwent vaccination: 129 (7%) >60 [1588 (92.5%) ≤60] and 676 (60%) ≤30 days from VCS. A bisexual orientation, a lower education level and a worse perceived physical and mental health were associated with delayed access to vaccination. Being Pre-Exposure Prophylaxis (PrEP) users and, marginally, HIV positive, having a high perceived risk for mpox infection and reporting high-risk behaviors like the use of recreational drugs/chems, sex under the influence of drugs and/or alcohol and higher number of principal sexual partners, were associated with early access to vaccination. Conclusions: according to our data, risk awareness was a major determinant of early mpox vaccination acceptance. Conversely, worse perceived health status and a low educational level were critical factors associated with delayed vaccination.

Mpox infection; mpox vaccination; risk awareness, vaccine acceptance; vaccine hesitancy; health-related quality of life; the Short-Form 36-item questionnaire

Public Health and Healthcare, Public Health and Health Services

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Risk Awareness as a Key Determinant of Early Vaccine Uptake in the Mpox Vaccination Campaign in an Italian Region: A Cross-Sectional Analysis

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