Gentiopicroside—The Biologically Active Plant Metabolite—An Insight into Its Pharmacological Significance and Future Perspectives

Lemonia Antoniadi; Magdalena Bartnik; Apostolis Angelis; Anna Wawruszak; Maria Halabalaki; Wirginia Kukula-Koch; Alexios-Leandros Skaltsounis

doi:10.20944/preprints202310.1375.v1

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preprints.org > medicine and pharmacology > pharmacy > doi: 10.20944/preprints202310.1375.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Gentiopicroside—The Biologically Active Plant Metabolite—An Insight into Its Pharmacological Significance and Future Perspectives

^* ,

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Alexios-Leandros Skaltsounis

Version 1 : Received: 20 October 2023 / Approved: 20 October 2023 / Online: 23 October 2023 (10:32:48 CEST)

How to cite: Antoniadi, L.; Bartnik, M.; Angelis, A.; Wawruszak, A.; Halabalaki, M.; Kukula-Koch, W.; Skaltsounis, A. Gentiopicroside—The Biologically Active Plant Metabolite—An Insight into Its Pharmacological Significance and Future Perspectives. Preprints 2023, 2023101375. https://doi.org/10.20944/preprints202310.1375.v1 Antoniadi, L.; Bartnik, M.; Angelis, A.; Wawruszak, A.; Halabalaki, M.; Kukula-Koch, W.; Skaltsounis, A. Gentiopicroside—The Biologically Active Plant Metabolite—An Insight into Its Pharmacological Significance and Future Perspectives. Preprints 2023, 2023101375. https://doi.org/10.20944/preprints202310.1375.v1

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MDPI and ACS Style

Antoniadi, L.; Bartnik, M.; Angelis, A.; Wawruszak, A.; Halabalaki, M.; Kukula-Koch, W.; Skaltsounis, A. Gentiopicroside—The Biologically Active Plant Metabolite—An Insight into Its Pharmacological Significance and Future Perspectives. Preprints 2023, 2023101375. https://doi.org/10.20944/preprints202310.1375.v1

APA Style

Antoniadi, L., Bartnik, M., Angelis, A., Wawruszak, A., Halabalaki, M., Kukula-Koch, W., & Skaltsounis, A. (2023). Gentiopicroside—The Biologically Active Plant Metabolite—An Insight into Its Pharmacological Significance and Future Perspectives. Preprints. https://doi.org/10.20944/preprints202310.1375.v1

Chicago/Turabian Style

Antoniadi, L., Wirginia Kukula-Koch and Alexios-Leandros Skaltsounis. 2023 "Gentiopicroside—The Biologically Active Plant Metabolite—An Insight into Its Pharmacological Significance and Future Perspectives" Preprints. https://doi.org/10.20944/preprints202310.1375.v1

Abstract

Gentiopicroside (GPS) is a leading component of several plant species from Gentianaceae botanical family. As a compound with plenty biological activities and a component that is often consumed in dietary supplements and herbal drugs, GPS has an important role in the regulation of physiological processes in humans. Recent studies on the type 2 receptors shed new light on GPS applications showing its agonistic properties that could be meaningful in the future therapeutic strategies of Parkinson’s disease, thyroid disorders or cancer states. This review aims to collect previously published reports on the biological properties of GPS as a single compound that were confirmed by in vitro and in vivo studies, and to draw attention at the newly discovered role of this bitter-tasting secoiridoid as a type 2 receptor agonist. Thanks to these properties, the research on this substance could be revisited.

Keywords

gentiopicroside; Gentianaceae; in vitro and in vivo pharmacological activity; molecular mechanism of bioactivity; health benefits; semisynthetic derivatives of gentiopicroside

Subject

Medicine and Pharmacology, Pharmacy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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