Version 1
: Received: 19 October 2023 / Approved: 19 October 2023 / Online: 23 October 2023 (05:18:14 CEST)
Version 2
: Received: 31 October 2023 / Approved: 1 November 2023 / Online: 1 November 2023 (05:25:53 CET)
How to cite:
Vagin, K.; Gaynutdinov, T.; Rakhmatullina, G.; Nizamov, R.; Gallyamova, M.; Sychev, K.; Semenov, V. Activation of the Immune System against the Background of Its Imbalance Caused by Agents of Radiation Nature. Preprints2023, 2023101368. https://doi.org/10.20944/preprints202310.1368.v2
Vagin, K.; Gaynutdinov, T.; Rakhmatullina, G.; Nizamov, R.; Gallyamova, M.; Sychev, K.; Semenov, V. Activation of the Immune System against the Background of Its Imbalance Caused by Agents of Radiation Nature. Preprints 2023, 2023101368. https://doi.org/10.20944/preprints202310.1368.v2
Vagin, K.; Gaynutdinov, T.; Rakhmatullina, G.; Nizamov, R.; Gallyamova, M.; Sychev, K.; Semenov, V. Activation of the Immune System against the Background of Its Imbalance Caused by Agents of Radiation Nature. Preprints2023, 2023101368. https://doi.org/10.20944/preprints202310.1368.v2
APA Style
Vagin, K., Gaynutdinov, T., Rakhmatullina, G., Nizamov, R., Gallyamova, M., Sychev, K., & Semenov, V. (2023). Activation of the Immune System against the Background of Its Imbalance Caused by Agents of Radiation Nature. Preprints. https://doi.org/10.20944/preprints202310.1368.v2
Chicago/Turabian Style
Vagin, K., Konstantin Sychev and Vladimir Semenov. 2023 "Activation of the Immune System against the Background of Its Imbalance Caused by Agents of Radiation Nature" Preprints. https://doi.org/10.20944/preprints202310.1368.v2
Abstract
By conjugating a radioantigen (o-quinone) with a protein - Esherichia coli endotoxin, a stable polyantigen complex-protein-quinoid radioantigen (BChA) - o-quinone imine (C6H10O-NH - protein) was obtained, including haptenic (o-quinone) and protein part of the antigenic complex (Esherichia coli endotoxin). Using the above components (hyperimmune antiradiotoxic serum, ethanol extract of the Vita-Force apiphitopreparation, metabolic products of Bifidobacterium bifidum, Bacillus subtilis and a highly dispersed fraction of bentonite), a polyfunctional composition «Polyapisogen» was compiled, including polyglobulins (500 cm3 per 1 L),500 cm3 of 4% ethanol extract of the Vita-Force apiphitopreparation, in which a highly dispersed fraction of bentonite (20 g), metabolism products (2 g powder) and Bacillus subtilis metabolism products (4 g) are dissolved. The polyfunctional preparation obtained by the above-described technology is used as an activator of the immune system against the background of its imbalance induced by agents of a radiogenic nature. It was found that a single subcutaneous injection of the drug at a dose of 25 mg / kg of live weight (dry matter basis) had a radioprotective effect increasing the survival rate of affected animals upto 75%. The studies carried out can serve as a basis for the creation of polyfunctional radioprotective, immunoprotective and bioprotective agents not only for isolated, but also for combined lesions of the body by agents of radiogenic and non-radiogenic nature using polyglobulins, convalescent serums, bee products, metabolic products of probiotic microorganisms and mineral sorbents.
Keywords
activator of the immune system; subpopulations of lymphocytes; polyglobulins; T-helpers (CD4); T-suppressors (CD8); radioprotector; hemoprotector; immunohemopoiesis
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Konstantin Vagin
Commenter's Conflict of Interests: Author