Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

HSF1 Inhibition: A Novel Anti-Cancer Strategy with Promise for Precision Oncology

Khanisyah Erza Gumilar
ORCID logo ,
Yeh Chin
,
Ibrahim H. Ibrahim
,
Brahmana A. Tjokroprawiro
,
Jer-Yen Yang
ORCID logo ,
Ming Zhou
ORCID logo ,
Natalie R. Gassman
ORCID logo ,
Ming Tan
*
Version 1 : Received: 20 October 2023 / Approved: 20 October 2023 / Online: 20 October 2023 (10:26:13 CEST)

A peer-reviewed article of this Preprint also exists.

Gumilar, K.E.; Chin, Y.; Ibrahim, I.H.; Tjokroprawiro, B.A.; Yang, J.-Y.; Zhou, M.; Gassman, N.R.; Tan, M. Heat Shock Factor 1 Inhibition: A Novel Anti-Cancer Strategy with Promise for Precision Oncology. Cancers 2023, 15, 5167. Gumilar, K.E.; Chin, Y.; Ibrahim, I.H.; Tjokroprawiro, B.A.; Yang, J.-Y.; Zhou, M.; Gassman, N.R.; Tan, M. Heat Shock Factor 1 Inhibition: A Novel Anti-Cancer Strategy with Promise for Precision Oncology. Cancers 2023, 15, 5167.

Abstract

Heat shock factor 1 (HSF1) is a transcription factor crucial for regulating heat shock response (HSR), one of the significant cellular protective mechanisms. When cells are exposed to proteotoxic stress, HSF1 induces the expression of heat shock proteins (HSPs) to act as chaperones, correcting the protein-folding process and maintaining proteostasis. In addition to its role in HSR, HSF1 is overexpressed in multiple cancer cells, where its activation promotes malignancy and leads to poor prognosis. The mechanisms of HSF1-induced tumorigenesis are complex and involve diverse signaling pathways, dependent on cancer type. With its important roles in tumorigenesis and tumor progression, targeting HSF1 offers a novel cancer treatment strategy. In this article, we examine the basic function of HSF1 and its regulatory mechanisms, focus on the mechanisms involved in HSF1’s roles in different cancer types, and examine current HSF1 inhibitors as novel therapeutics to treat cancers.

Keywords

HSF1; heat shock response; cellular stress; cancer stem cells; tumor microenvironment

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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