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Some Aspects of a-(Acyloxy)alkyl Radicals in Organic Synthesis
Version 1
: Received: 19 October 2023 / Approved: 19 October 2023 / Online: 19 October 2023 (07:31:36 CEST)
A peer-reviewed article of this Preprint also exists.
Quiclet-Sire, B.; Zard, S.Z. Some Aspects of α-(Acyloxy)alkyl Radicals in Organic Synthesis. Molecules 2023, 28, 7561. Quiclet-Sire, B.; Zard, S.Z. Some Aspects of α-(Acyloxy)alkyl Radicals in Organic Synthesis. Molecules 2023, 28, 7561.
Abstract
The preparation and use of -(acyloxy)alkyl xanthates to generate and capture -(acyloxy)alkyl radicals is briefly reviewed. Their inter- and intramolecular additions to both activated and unactivated, electronically unbiased, alkenes, and to (hetero)aromatic rings, as well as their radical allylation and vinylation reactions are described. Application to the total synthesis of two 4-hydroxytetralone natural products is also presented.
Keywords
radical additions; xanthates; a-(acyloxy)alkyl radicals; enones
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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