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Viruses and Cajal Bodies: A Critical Cellular Target in Virus Infection?
Version 1
: Received: 17 October 2023 / Approved: 18 October 2023 / Online: 18 October 2023 (11:46:56 CEST)
A peer-reviewed article of this Preprint also exists.
Lettin, L.; Erbay, B.; Blair, G.E. Viruses and Cajal Bodies: A Critical Cellular Target in Virus Infection? Viruses 2023, 15, 2311. Lettin, L.; Erbay, B.; Blair, G.E. Viruses and Cajal Bodies: A Critical Cellular Target in Virus Infection? Viruses 2023, 15, 2311.
Abstract
Nuclear bodies (NBs) are dynamic structures present in eukaryotic cell nuclei. They are not bounded by membranes and are often considered biomolecular condensates, defined structurally and functionally by the localisation of core components. Nuclear architecture can be reorganised during normal cellular processes such as the cell cycle as well as in response to cellular stress. Many plant and animal viruses target their proteins to NBs, in some cases triggering their structural disruption and redistribution. Although not all such interactions have been well characterised, subversion of NBs and their functions may form a key part of the life cycle of eukaryotic viruses that require the nucleus for their replication. This review will focus on Cajal bodies (CBs) and the viruses that target them. Since CBs are dynamic structures, other NBs (principally nucleoli and promyelocytic leukaemia, PML, bodies), whose components interact with CBs, will also be considered. As well as providing important insights into key virus: host cell interactions, studies on Cajal and associated NBs may identify novel cellular targets for development of anti-viral compounds.
Keywords
nuclear bodies; cajal bodies; PML bodies; nucleolus; snRNPs; animal viruses; plant viruses; nuclear remodelling
Subject
Biology and Life Sciences, Virology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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