Wang, Y.; Meng, Y.; Wang, Y.; Yuan, S.; Li, Y.; Feng, Y.; Wang, Z. Application of Multiscale Hierarchical Porous Structure Design in Bone Tissue Engineering Scaffolds: A Review. Preprints2023, 2023101082. https://doi.org/10.20944/preprints202310.1082.v1
APA Style
Wang, Y., Meng, Y., Wang, Y., Yuan, S., Li, Y., Feng, Y., & Wang, Z. (2023). Application of Multiscale Hierarchical Porous Structure Design in Bone Tissue Engineering Scaffolds: A Review. Preprints. https://doi.org/10.20944/preprints202310.1082.v1
Chicago/Turabian Style
Wang, Y., Yanhuizhi Feng and Zuolin Wang. 2023 "Application of Multiscale Hierarchical Porous Structure Design in Bone Tissue Engineering Scaffolds: A Review" Preprints. https://doi.org/10.20944/preprints202310.1082.v1
Abstract
In recent decades, porous scaffolds for bone tissue engineering (BTE) have gained significant attention. Considerable research efforts have been dedicated to investigating the impact of scaffold pore size on a diverse array of biological processes, including cell-scaffold interactions, substance transportation, and vascularization. However, the multi-scale hierarchical porosity, a key structural characteristic of natural bone, has rarely been replicated in BTE scaffolds due to the challenges of controlling the scaffold structure across multiple length scales. With the advancement of manufacturing technology, there has been increasing research on biomimetic multi-scale hierarchical materials, which are also gaining favor in the field of BTE. Therefore, there is an urgent need to review multi-scale hierarchical porous BTE scaffolds. This paper aims to review the role and fabrication methods of multi-scale porous BTE scaffolds at different length scales, the design and manufacturing of new BTE scaffolds for bone regeneration.
Keywords
multi-scale; hierarchical structure; porous scaffold; bone tissue engineering; bone regeneration
Subject
Chemistry and Materials Science, Biomaterials
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
