Adiponectin: A Promising Target for the Treatment of Diabetes and Its Complications

Mahmuda Begum; Mayank Choubey; Munichandra Babu Tirumalasetty; Mohammad Mohabbulla Mohib; Md. Wahiduzzaman; Mohammed A. Mamun; Shahida Arbee; Mohammad Sarif Mohiuddin

doi:10.20944/preprints202310.0782.v1

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preprints.org > medicine and pharmacology > endocrinology and metabolism > doi: 10.20944/preprints202310.0782.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Adiponectin: A Promising Target for the Treatment of Diabetes and Its Complications

Mahmuda Begum

Mayank Choubey

Munichandra Babu Tirumalasetty

Mohammad Mohabbulla Mohib

Md. Wahiduzzaman

Mohammed A. Mamun

Shahida Arbee

Mohammad Sarif Mohiuddin

Version 1 : Received: 10 October 2023 / Approved: 12 October 2023 / Online: 12 October 2023 (20:09:06 CEST)

A peer-reviewed article of this Preprint also exists.

Begum, M., Choubey, M., Tirumalasetty, M. B., Arbee, S., Mohib, M. M., Wahiduzzaman, M., ... & Mohiuddin, M. S. (2023). Adiponectin: a promising target for the treatment of diabetes and its complications. Life, 13(11), 2213. Begum, M., Choubey, M., Tirumalasetty, M. B., Arbee, S., Mohib, M. M., Wahiduzzaman, M., ... & Mohiuddin, M. S. (2023). Adiponectin: a promising target for the treatment of diabetes and its complications. Life, 13(11), 2213.

Abstract

Diabetes mellitus, a chronic metabolic disorder characterized by hyperglycemia, presents a formidable global health challenge with its associated complications. Adiponectin, an adipocyte-derived hormone, has emerged as a significant player in glucose metabolism and insulin sensitivity. Beyond its metabolic effects, adiponectin exerts anti-inflammatory, anti-oxidative, and vasoprotective properties, making it an appealing therapeutic target for mitigating diabetic complications. The molecular mechanisms by which adiponectin impacts critical pathways implicated in diabetic nephropathy, retinopathy, neuropathy, and cardiovascular problems are thoroughly examined in this study. In addition, we explore possible treatment options for increasing adiponectin levels or improving its downstream signaling. The multifaceted protective roles of adiponectin in diabetic complications suggest its potential as a novel therapeutic avenue. However, further translational studies and clinical trials are warranted to fully harness the therapeutic potential of adiponectin in the management of diabetic complications. This review highlights adiponectin as a promising target for the treatment of diverse diabetic complications and encourages continued research in this pivotal area of diabetes therapeutics.

Keywords

adiponectin; adiporon; diabetes; Adipo1; Adipo 2

Subject

Medicine and Pharmacology, Endocrinology and Metabolism

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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