Version 1
: Received: 10 October 2023 / Approved: 11 October 2023 / Online: 11 October 2023 (04:43:52 CEST)
How to cite:
Giese, M. Vaccinating against Cancer – How to Force the Quatrature of the Circle. Preprints2023, 2023100669. https://doi.org/10.20944/preprints202310.0669.v1
Giese, M. Vaccinating against Cancer – How to Force the Quatrature of the Circle. Preprints 2023, 2023100669. https://doi.org/10.20944/preprints202310.0669.v1
Giese, M. Vaccinating against Cancer – How to Force the Quatrature of the Circle. Preprints2023, 2023100669. https://doi.org/10.20944/preprints202310.0669.v1
APA Style
Giese, M. (2023). Vaccinating against Cancer – How to Force the Quatrature of the Circle. Preprints. https://doi.org/10.20944/preprints202310.0669.v1
Chicago/Turabian Style
Giese, M. 2023 "Vaccinating against Cancer – How to Force the Quatrature of the Circle" Preprints. https://doi.org/10.20944/preprints202310.0669.v1
Abstract
There are compelling evidences that the immune system is to confer protection not only against foreign pathogens but also against cancer. But if the immune system can’t detect every malignant cell, and at the same time a suitable tumor microenvironment (TME) is formed by inflammatory processes, a carcinogenesis is not longer to be blocked. Once the tumor cells have found their niche, the tumor cells are trained by immune cells turned inside out in how to deal with the immune system "out there". The TME is a training camp and protected space for tumor cells. The Corona crisis has revived a therapeutic approach that was thought to be almost dead: RNA vaccines. Despite decades of research and many clinical studies, no registered RNA cancer vaccine exists today. But the SARS-CoV-2 RNA vaccines against COVID-19 disease have demonstrated their dangerous weaknesses. RNA vaccines manipulate the innate immunity and make the body susceptible to any viral infection. There is also the possibility of integration into the genome. The few approved therapeutic cancer vaccines show little effect. Despite some successes, immunotherapies remain ineffective for most patients with cancer. Powerful therapeutic cancer vaccines remain an unfulfilled dream, a misconception.
Keywords
Cancer biology; tumor immunology; neoantigens; T cell exhaustion; immunosenescence; cancer vaccines; RNA vaccines
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
