Examination of the Antioxidant and Anti-Inflammatory Effects of Extracts from the Bark of Bangladesh Medicinal Plants

Joo Won Lee; Mi-Bo Kim; Seungjin Jeong; Hyeju Lee; Su Hyeon Baek; Md. Salah Uddin; Sang Woo Lee; Sang Gil Lee

doi:10.20944/preprints202310.0655.v1

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preprints.org > biology and life sciences > food science and technology > doi: 10.20944/preprints202310.0655.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Examination of the Antioxidant and Anti-Inflammatory Effects of Extracts from the Bark of Bangladesh Medicinal Plants

Version 1 : Received: 9 October 2023 / Approved: 9 October 2023 / Online: 11 October 2023 (06:30:43 CEST)

A peer-reviewed article of this Preprint also exists.

Lee, J.W.; Kim, M.-B.; Jeong, S.; Lee, H.; Baek, S.H.; Uddin, Md.S.; Lee, S.W.; Lee, S.G. Examination of the Antioxidant and Anti-Inflammatory Effects of Extracts from the Bark of Bangladesh Medicinal Plants. Food Engineering Progress 2024, 28, 10–19, doi:10.13050/foodengprog.2024.28.1.10. Lee, J.W.; Kim, M.-B.; Jeong, S.; Lee, H.; Baek, S.H.; Uddin, Md.S.; Lee, S.W.; Lee, S.G. Examination of the Antioxidant and Anti-Inflammatory Effects of Extracts from the Bark of Bangladesh Medicinal Plants. Food Engineering Progress 2024, 28, 10–19, doi:10.13050/foodengprog.2024.28.1.10.

Abstract

Bangladeshi medicinal plants (BMP) have been used as traditional medicinal plants to treat chronic inflammatory diseases, but the antioxidant and anti-inflammatory effects of the bark of BMP are not yet known. The objective of this study was to determine antioxidant and anti-inflammatory activities using methanolic extracts of bark obtained from 15 medicinal spices of Bangladesh plants. The bark methanol extracts of BMP evaluated the total antioxidant activity and anti-inflammatory effect of lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 macrophages. Among the 15 bark extracts of BMP, Albizia odoratissima (A. odoratissima), Engelhardia spicata (E. spicata), and Shorea robusta (S. robusta) showed the highest total phenolic contents and total antioxidant capacity by reducing free radicals scavenging activity. In particular, the three bark extracts significantly reduced the mRNA expression of LPS-induced inflammatory cytokines and inflammation-inducible enzymes in macrophages. Also, the mRNA expression of NADPH oxidase 2 was significantly suppressed by three bark extracts in LPS-induced RAW 264.7 macrophages. The results suggest that among the 15 bark extracts obtained from medicinal plant in Bangladesh, three bark extracts of A. odoratissima, E. spicata, and S. robusta exert total antioxidant capacity by reducing free radicals scavenging activity and inhibitory effects on LPS-stimulated inflammation in macrophages.

Keywords

Bangladeshi medicinal plants; antioxidant; anti-inflammatory

Subject

Biology and Life Sciences, Food Science and Technology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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