Preprint Interesting Images Version 1 Preserved in Portico This version is not peer-reviewed

SpyGlass Cholangioscopy for Indeterminate Biliary Stricture in a Patient with Primary Sclerosing Cholangitis

Version 1 : Received: 8 October 2023 / Approved: 8 October 2023 / Online: 9 October 2023 (08:51:11 CEST)

How to cite: Chin, N.-H.; Chen, K.-C.; Chen, K.-H.; Lee, T.-H.; Wang, H.-P.; Chung, C.-S. SpyGlass Cholangioscopy for Indeterminate Biliary Stricture in a Patient with Primary Sclerosing Cholangitis. Preprints 2023, 2023100450. https://doi.org/10.20944/preprints202310.0450.v1 Chin, N.-H.; Chen, K.-C.; Chen, K.-H.; Lee, T.-H.; Wang, H.-P.; Chung, C.-S. SpyGlass Cholangioscopy for Indeterminate Biliary Stricture in a Patient with Primary Sclerosing Cholangitis. Preprints 2023, 2023100450. https://doi.org/10.20944/preprints202310.0450.v1

Abstract

SpyGlass peroral cholangioscopy (POCS) has greatly improved the diagnosis of biliary strictures by allowing direct visualization and tissue sampling in the bile ducts. Supported by strong registry data and careful analysis, POCS is highly accurate in diagnosis and carries minimal risks. It plays a pivotal role in diagnosis of indeterminate biliary stricture like primary sclerosing cholangitis (PSC), which increases the risk of cancer. POCS facilitates early disease detection through distinctive endoscopic observations and provides essential information with directed biopsies that assess inflammation and potential malignancy. This case study showcased POCS's diagnostic ability when it accurately identified benign findings in a 59-year-old patient with jaundice. Treatment with ursodeoxycholic acid resulted in significant improvements, highlighting the diagnostic performance of POCS. In summary, POCS simplifies complex biliary stricture cases, expedites diagnosis and intervention, and significantly contributes to improving patient outcomes in challenging hepatobiliary conditions.

Keywords

cholangioscopy; primary sclerosing cholangitis; SpyGlass; biliary stricture

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

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