Novel insights into the molecular mechanisms governing embryonic epicardium formation

Rita Carmona; Carmen Lopez-Sanchez; Virginio Garcia-Martinez; Virginio García-López; Ramón Muñoz-Chápuli; Estefanía Lozano-Velasco; Diego Franco

doi:10.20944/preprints202310.0363.v1

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preprints.org > biology and life sciences > cell and developmental biology > doi: 10.20944/preprints202310.0363.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Novel insights into the molecular mechanisms governing embryonic epicardium formation

Rita Carmona

Carmen Lopez-Sanchez

Virginio Garcia-Martinez

Virginio García-López

Ramón Muñoz-Chápuli

Estefanía Lozano-Velasco

Diego Franco

Version 1 : Received: 6 October 2023 / Approved: 6 October 2023 / Online: 9 October 2023 (15:04:52 CEST)

A peer-reviewed article of this Preprint also exists.

Carmona, R.; López-Sánchez, C.; Garcia-Martinez, V.; Garcia-López, V.; Muñoz-Chápuli, R.; Lozano-Velasco, E.; Franco, D. Novel Insights into the Molecular Mechanisms Governing Embryonic Epicardium Formation. J. Cardiovasc. Dev. Dis. 2023, 10, 440. Carmona, R.; López-Sánchez, C.; Garcia-Martinez, V.; Garcia-López, V.; Muñoz-Chápuli, R.; Lozano-Velasco, E.; Franco, D. Novel Insights into the Molecular Mechanisms Governing Embryonic Epicardium Formation. J. Cardiovasc. Dev. Dis. 2023, 10, 440.

Abstract

The embryonic epicardium originates from the proepicardium, an extracardiac primordium constituted by a cluster of mesothelial cells. In early embryos, the embryonic epicardium is characterized by a squamous cell epithelium resting on the myocardium surface. Subsequently, it invades the subepicardial space and thereafter the embryonic myocardium by means of epithelial-mesenchymal transition. Within the myocardium, epicardial-derived cells present multilineage potential, later differentiating into smooth muscle cells and contributing both to coronary vasculature and cardiac fibroblasts in the mature heart. Over the last decades, we have progressively increased our understanding of those cellular and molecular mechanisms driving proepicardial/embryonic epicardium formation. This study provides a state-of-the-art review of the transcriptional and emerging post-transcriptional mechanisms involved in the formation and differentiation of the embryonic epicardium.

Keywords

proepicardium, epicardium, transcriptional, post-transcriptional

Subject

Biology and Life Sciences, Cell and Developmental Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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