Version 1
: Received: 6 October 2023 / Approved: 6 October 2023 / Online: 6 October 2023 (11:21:00 CEST)
How to cite:
Boiangiu, R.S.; Brinza, I.; Honceriu, I.; Mihasan, M.; Hritcu, L. Insights into the Brain Effects of a Bacterial Nicotine Derivative – 6-Hydroxy-L-Nicotine. Preprints2023, 2023100340. https://doi.org/10.20944/preprints202310.0340.v1
Boiangiu, R.S.; Brinza, I.; Honceriu, I.; Mihasan, M.; Hritcu, L. Insights into the Brain Effects of a Bacterial Nicotine Derivative – 6-Hydroxy-L-Nicotine. Preprints 2023, 2023100340. https://doi.org/10.20944/preprints202310.0340.v1
Boiangiu, R.S.; Brinza, I.; Honceriu, I.; Mihasan, M.; Hritcu, L. Insights into the Brain Effects of a Bacterial Nicotine Derivative – 6-Hydroxy-L-Nicotine. Preprints2023, 2023100340. https://doi.org/10.20944/preprints202310.0340.v1
APA Style
Boiangiu, R.S., Brinza, I., Honceriu, I., Mihasan, M., & Hritcu, L. (2023). Insights into the Brain Effects of a Bacterial Nicotine Derivative – 6-Hydroxy-L-Nicotine. Preprints. https://doi.org/10.20944/preprints202310.0340.v1
Chicago/Turabian Style
Boiangiu, R.S., Marius Mihasan and Lucian Hritcu. 2023 "Insights into the Brain Effects of a Bacterial Nicotine Derivative – 6-Hydroxy-L-Nicotine" Preprints. https://doi.org/10.20944/preprints202310.0340.v1
Abstract
The purported cognitive benefits associated with nicotine and its metabolites in the brain are a matter of debate. In this review, the impact of the pharmacologically active metabolite of a nicotine derivative produced by bacteria (6-hydroxy-L-nicotine) on memory, oxidative stress, and the activity of the cholinergic system in the brain was examined. A search in the PubMed, Science Direct, Web of Science, and Google Scholar databases, limiting entries to those no later than July 2023, was conducted. The search focused specifically on articles pertaining to nicotine metabolites, memory, oxidative stress, cholinergic system activity, as well as enzymes or pathways related to nicotine degradation in bacteria. The preliminary search resulted in 696 articles, and following the application of exclusion criteria, 185 articles were deemed eligible for inclusion. This review focuses on experimental studies supporting nicotine catabolism in bacteria, and the chemical and pharmacological activities of nicotine and its metabolite 6-hydroxy-L-nicotine.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
