Review
Version 1
Preserved in Portico This version is not peer-reviewed
Ramifications of m6A Modification on ncRNAs in Cancer
Version 1
: Received: 4 October 2023 / Approved: 5 October 2023 / Online: 5 October 2023 (08:24:03 CEST)
How to cite: Mehmood, R. Ramifications of m6A Modification on ncRNAs in Cancer. Preprints 2023, 2023100266. https://doi.org/10.20944/preprints202310.0266.v1 Mehmood, R. Ramifications of m6A Modification on ncRNAs in Cancer. Preprints 2023, 2023100266. https://doi.org/10.20944/preprints202310.0266.v1
Abstract
N6-methyladenosine (m6A) is an RNA modification wherein N6-position of adenosine is methylated. It is one of the most prevalent internal modifications on RNA and regulates various aspects of RNA metabolism. M6A is deposited by m6A methyltransferases, removed by m6A demethylases and recognized by reader proteins, which modulate splicing, export, translation and stability of the modified mRNA. Recently evidence suggests that various classes of non-coding RNAs (ncRNAs) including microRNAs (miRNAs), circular RNAs (circRNAs), and long con-coding RNAs (lncRNAs) are also targeted by this modification. Depending on the ncRNA species, m6A may affect processing, stability, or localization of these molecules. The m6A modified ncRNAs are implicated in a number of diseases including cancer. In this review, I summarize the role of m6A modification in the regulation and function of ncRNAs in tumor development. Moreover, the potential applications in cancer prognosis and therapeutics is discussed.
Keywords
ncRNAs; m6A modification; cancer
Subject
Biology and Life Sciences, Biology and Biotechnology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment
