Version 1
: Received: 2 October 2023 / Approved: 4 October 2023 / Online: 4 October 2023 (09:09:47 CEST)
Version 2
: Received: 9 October 2023 / Approved: 10 October 2023 / Online: 10 October 2023 (10:12:09 CEST)
How to cite:
Angelo, M.; Bhargava, Y.; Aoki, S. A Primer for Junior Trainees: Recognition of RNA Modifications by Binding Proteins. Preprints2023, 2023100213. https://doi.org/10.20944/preprints202310.0213.v2
Angelo, M.; Bhargava, Y.; Aoki, S. A Primer for Junior Trainees: Recognition of RNA Modifications by Binding Proteins. Preprints 2023, 2023100213. https://doi.org/10.20944/preprints202310.0213.v2
Angelo, M.; Bhargava, Y.; Aoki, S. A Primer for Junior Trainees: Recognition of RNA Modifications by Binding Proteins. Preprints2023, 2023100213. https://doi.org/10.20944/preprints202310.0213.v2
APA Style
Angelo, M., Bhargava, Y., & Aoki, S. (2023). A Primer for Junior Trainees: Recognition of RNA Modifications by Binding Proteins. Preprints. https://doi.org/10.20944/preprints202310.0213.v2
Chicago/Turabian Style
Angelo, M., Yash Bhargava and Scott Aoki. 2023 "A Primer for Junior Trainees: Recognition of RNA Modifications by Binding Proteins" Preprints. https://doi.org/10.20944/preprints202310.0213.v2
Abstract
The complexity of RNA cannot be fully expressed with the canonical A, C, G, and U alphabet. To date, over 140 distinct chemical modifications to RNA have been discovered. RNA modifications can profoundly impact the cellular outcomes of messenger RNAs (mRNAs), transfer and ribosomal RNAs, and noncoding RNAs. Additionally, aberrant RNA modifications are associated with human disease. RNA modifications are a rising topic within the fields of biochemistry and molecular biology. This review aims to provide budding scientists with an appreciation for the significance of RNA modifications, alongside the skills required to identify and fluently discuss fundamental RNA-protein interactions. The Pumilio RNA-binding protein and YT521-B homology (YTH) family of modified RNA-binding proteins serve as examples to highlight the fundamental biochemical interactions that underlie the specific recognition of both unmodified and modified ribonucleotides, respectively.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Scott Aoki
Commenter's Conflict of Interests: Author