Targeting Interleukin-17 as Novel Treatment Option for Fibrotic Diseases

Margherita Sisto; Sabrina Lisi

doi:10.20944/preprints202310.0168.v1

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preprints.org > biology and life sciences > immunology and microbiology > doi: 10.20944/preprints202310.0168.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Targeting Interleukin-17 as Novel Treatment Option for Fibrotic Diseases

Margherita Sisto

^* and

Sabrina Lisi

Version 1 : Received: 2 October 2023 / Approved: 3 October 2023 / Online: 3 October 2023 (15:25:03 CEST)

A peer-reviewed article of this Preprint also exists.

Sisto, M.; Lisi, S. Targeting Interleukin-17 as a Novel Treatment Option for Fibrotic Diseases. J. Clin. Med. 2024, 13, 164. Sisto, M.; Lisi, S. Targeting Interleukin-17 as a Novel Treatment Option for Fibrotic Diseases. J. Clin. Med. 2024, 13, 164.

Abstract

Fibrosis is the end result of persistent inflammatory responses induced by a variety of stimuli, including chronic infections, autoimmune reactions, and tissue injury. Fibrotic diseases affect all vital organs and are characterized by a high rate of morbidity and mortality in the developed world, although currently there are no approved antifibrotic therapies. In recent years, high levels of interleukin-17 (IL-17) have been associated with chronic inflammatory diseases with fibrotic complications, that culminate in organ failure. In this review, we provide an update on the role of IL-17 in fibrotic diseases, with particular attention to the most recent lines of research in the therapeutic field represented by the epigenetic mechanisms that control IL-17 levels in fibrosis. A better knowledge of the IL-17 signalling pathway implications in fibrosis could design new strategies for therapeutic benefits.

Keywords

IL-17; fibrosis; autoimmune; epigenetics; biological drugs.

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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