Review
Version 1
Preserved in Portico This version is not peer-reviewed
Maladaptive T-Cell Metabolic Fitness in Autoimmune Diseases
Version 1
: Received: 27 September 2023 / Approved: 28 September 2023 / Online: 28 September 2023 (09:01:58 CEST)
A peer-reviewed article of this Preprint also exists.
Antony, I.R.; Wong, B.H.S.; Kelleher, D.; Verma, N.K. Maladaptive T-Cell Metabolic Fitness in Autoimmune Diseases. Cells 2023, 12, 2541. Antony, I.R.; Wong, B.H.S.; Kelleher, D.; Verma, N.K. Maladaptive T-Cell Metabolic Fitness in Autoimmune Diseases. Cells 2023, 12, 2541.
Abstract
Immune surveillance and adaptive immune responses, involving continuously circulating and tissue-resident T-lymphocytes, provide host defense against infectious agents and possible malignant transformation while avoiding autoimmune tissue damage. Activation, migration, and deployment of T-cells to affected tissue sites are crucial for mounting an adaptive immune response. An effective adaptive immune defense depends on the ability of T-cells to dynamically reprogram their metabolic requirements in response to environmental cues. Inability of the T-cells to adapt to specific metabolic demands may skew cells to become either hyporesponsive creating immunocompromised conditions or hyperactive causing autoimmune tissue destruction. Here, we review maladaptive T-cell metabolic fitness that can cause autoimmune diseases and discuss how T-cell metabolic programs can potentially be modulated to achieve therapeutic benefits.
Keywords
autoimmunity; glycolysis; metabolites; psoriasis; rheumatoid arthritis; T-cell function; T-cell motility; T-lymphocytes
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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