Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Long-Term Outcomes and Prognosis of Patients with Myocardial Infarction During Covid Pandemic

Marius Rus
* ORCID logo ,
Adriana Ioana Ardelean
,
Ana Maria Jurcau
ORCID logo ,
Felicia Liana Andronie-Cioara
ORCID logo ,
Paula Marian
,
Oana Lilliana Pobirci
,
Veronica Huplea
,
Alina Stanca Osiceanu
,
Adrian Gheorghe Osiceanu
,
Simina Crisan
,
Georgiana Carmen Filimon
Version 1 : Received: 26 September 2023 / Approved: 27 September 2023 / Online: 27 September 2023 (11:29:44 CEST)

How to cite: Rus, M.; Ardelean, A. I.; Jurcau, A. M.; Andronie-Cioara, F. L.; Marian, P.; Pobirci, O. L.; Huplea, V.; Osiceanu, A. S.; Osiceanu, A. G.; Crisan, S.; Filimon, G. C. Long-Term Outcomes and Prognosis of Patients with Myocardial Infarction During Covid Pandemic. Preprints 2023, 2023091863. https://doi.org/10.20944/preprints202309.1863.v1 Rus, M.; Ardelean, A. I.; Jurcau, A. M.; Andronie-Cioara, F. L.; Marian, P.; Pobirci, O. L.; Huplea, V.; Osiceanu, A. S.; Osiceanu, A. G.; Crisan, S.; Filimon, G. C. Long-Term Outcomes and Prognosis of Patients with Myocardial Infarction During Covid Pandemic. Preprints 2023, 2023091863. https://doi.org/10.20944/preprints202309.1863.v1

Abstract

Coronavirus infection disease -2019 (COVID-19) was a global pandemic with high mortality and morbidity, that lead to an increased health burned all over the world. Although the virus affects mostly pulmonary tract, cardiovascular implications were often among COVID-19 positive patients, and are predictive for poor outcomes. Increased values of myocardial biomarkers such as Troponin I or NT-proBNP were proven to be risk factors for respiratory failure (26). Although the risk of acute coronary syndromes (ACS) was greater in acute-phase of COVID-19, there were lower rates of hospitalization for ACS, due to patient’s hesitation for presenting at the hospital (22). Hospitalized ACS patients with COVID-19 infection, had a prolonged symptom-to-first medical contact time, and longer door-to-balloon time. The mechanisms of myocardial injurie in COVID -19 patients are not still not clear, most often is incriminated: the down-regulation of ACE2 inhibitors, endothelial disfunction, pro-coagulant status, increased levels of pro-inflammatory cytokines. The aim of this paper is to evaluate the long-term outcomes of COVID-19 survivors that presented an acute myocardial infarction by reviewing existing data.

Keywords

COVID 19; myocardial infarction; cardiovascular burden; long-term outcomes; acute coronary syndrome

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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