Dos Santos Neto, J.V.; Medina, J.M.; Teixeira, K.D.; Chorev, M.; Diotallevi, A.; Aktas, B.H.; Galluzzi, L.; Lopes, U.G. Activity of the Di-Substituted Urea-Derived Compound I-17 in Leishmania Infections. Preprints2023, 2023091754. https://doi.org/10.20944/preprints202309.1754.v1
APA Style
Dos Santos Neto, J.V., Medina, J.M., Teixeira, K.D., Chorev, M., Diotallevi, A., Aktas, B.H., Galluzzi, L., & Lopes, U.G. (2023). Activity of the Di-Substituted Urea-Derived Compound I-17 in Leishmania Infections. Preprints. https://doi.org/10.20944/preprints202309.1754.v1
Chicago/Turabian Style
Dos Santos Neto, J.V., Luca Galluzzi and Ulisses Gazos Lopes. 2023 "Activity of the Di-Substituted Urea-Derived Compound I-17 in Leishmania Infections" Preprints. https://doi.org/10.20944/preprints202309.1754.v1
Abstract
Protein synthesis has been a very rich target for developing classes of drugs to control prokaryotic and eukaryotic pathogens. Despite the development of new drug formulations, treating human cutaneous and visceral Leishmaniasis still needs significant improvement due to considerable side effects and low adherence to the usual treatment regimen. In this work, we show that the di-substituted urea-derived compound I-17 is effective in inhibiting the promastigote forms and intracellular amastigotes of the Leishmania (L.) amazonensis and L. infantum species, in addition to exhibiting low macrophage cytotoxicity. We also show a potential immunomodulatory effect of I-17 in infected macrophages, which exhibited increased expression of inducible Nitric Oxide Synthase (NOS2) and Nitric Oxide (NO) production. Our data suggest that I-17 and new derivatives of this compound may be helpful in developing new drugs for treating leishmaniasis.
Keywords
Leishmania,; treatment; I-17; eIF2alpha
Subject
Biology and Life Sciences, Parasitology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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