Version 1
: Received: 23 September 2023 / Approved: 25 September 2023 / Online: 26 September 2023 (04:43:19 CEST)
How to cite:
Sauren, J.; Höhfeld, D.; Keferstein, L.G. Efficacy of Mitochondrial-Based Interventions in the Management of Crohn’s Disease- A Systematic Review. Preprints2023, 2023091722. https://doi.org/10.20944/preprints202309.1722.v1
Sauren, J.; Höhfeld, D.; Keferstein, L.G. Efficacy of Mitochondrial-Based Interventions in the Management of Crohn’s Disease- A Systematic Review. Preprints 2023, 2023091722. https://doi.org/10.20944/preprints202309.1722.v1
Sauren, J.; Höhfeld, D.; Keferstein, L.G. Efficacy of Mitochondrial-Based Interventions in the Management of Crohn’s Disease- A Systematic Review. Preprints2023, 2023091722. https://doi.org/10.20944/preprints202309.1722.v1
APA Style
Sauren, J., Höhfeld, D., & Keferstein, L.G. (2023). Efficacy of Mitochondrial-Based Interventions in the Management of Crohn’s Disease- A Systematic Review. Preprints. https://doi.org/10.20944/preprints202309.1722.v1
Chicago/Turabian Style
Sauren, J., David Höhfeld and Leif Gerrit Keferstein. 2023 "Efficacy of Mitochondrial-Based Interventions in the Management of Crohn’s Disease- A Systematic Review" Preprints. https://doi.org/10.20944/preprints202309.1722.v1
Abstract
ABSTRACTBackground: Crohn's disease (CD) is a chronic inflammatory bowel disorder with limited treatment options. Mitochondrial dysfunction has been implicated in CD pathogenesis, and mitochondrial-based interventions have emerged as a potential therapeutic avenue. This systematic review aimed to assess the efficacy of mitochondrial-based interventions in the management of CD.Methods: A systematic search of multiple databases was conducted to identify relevant studies in accordance with the PRISMA protocol. Inclusion criteria encompassed studies investigating mitochondrial-targeted interventions in CD patients. Methodological quality and risk of bias assessments were performed. Data synthesis involved both quantitative meta-analysis and qualitative narrative synthesis.Results: A total of 23 studies were included in this review, comprising randomized controlled trials, observational studies, and case reports. Mitochondrial-based interventions encompassed nutraceuticals, probiotics, exercise, and dietary modifications. However, the overall quality of evidence was moderate, primarily due to methodological limitations in some studies.Conclusion: This systematic review suggests that mitochondrial-based interventions hold promise as adjunctive therapies for CD management. They appear to contribute to clinical remission and amelioration of disease activity. Nevertheless, the moderate quality of evidence underscores the need for further well-designed clinical trials to substantiate these findings and delineate optimal intervention strategies.
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
