Version 1
: Received: 11 September 2023 / Approved: 22 September 2023 / Online: 22 September 2023 (10:18:19 CEST)
How to cite:
Sauren, J.; Hoehfeld, D.; Keferstein, L.G. Efficacy of Mitochondrial-Based Interventions in the Management of Clinical Depression—A Systematic Review. Preprints2023, 2023091547. https://doi.org/10.20944/preprints202309.1547.v1
Sauren, J.; Hoehfeld, D.; Keferstein, L.G. Efficacy of Mitochondrial-Based Interventions in the Management of Clinical Depression—A Systematic Review. Preprints 2023, 2023091547. https://doi.org/10.20944/preprints202309.1547.v1
Sauren, J.; Hoehfeld, D.; Keferstein, L.G. Efficacy of Mitochondrial-Based Interventions in the Management of Clinical Depression—A Systematic Review. Preprints2023, 2023091547. https://doi.org/10.20944/preprints202309.1547.v1
APA Style
Sauren, J., Hoehfeld, D., & Keferstein, L.G. (2023). Efficacy of Mitochondrial-Based Interventions in the Management of Clinical Depression—A Systematic Review. Preprints. https://doi.org/10.20944/preprints202309.1547.v1
Chicago/Turabian Style
Sauren, J., David Hoehfeld and Leif Gerrit Keferstein. 2023 "Efficacy of Mitochondrial-Based Interventions in the Management of Clinical Depression—A Systematic Review" Preprints. https://doi.org/10.20944/preprints202309.1547.v1
Abstract
Background: Depression, a multifaceted mental health condition, necessitates a multidimensional approach to treatment. This study aimed to elucidate the potential efficacy of various mitochondrial interventions, ranging from pharmacological treatments to lifestyle modifications, in alleviating depressive symptoms and enhancing overall mental well-being and assess the diverse range of mitochondrial assessments for managing depression by synthesizing findings from selected studies. Methods: A systematic compilation of studies, employing observational, interventional, and animal-based designs, was undertaken to elucidate the intricate relationship between mitochondrial function and depression as well as depressive signs and symptoms. The PRISMA guidelines were employed for conducting this review and a specific set of selection criterion were formulated by a team of reviewers for selection of relevant papers. Results: The synthesized results from the 21 selected papers highlighted the potential of these interventions to target diverse aspects of depression. Hyperbaric oxygen therapy and psychotherapy demonstrated significant reductions in depression and anxiety scores, with hyperbaric oxygen therapy particularly effective in improving nerve function and daily living activities. Whole-body cryotherapy displayed substantial improvements in depressive symptoms and quality of life. Frequent sauna bathing exhibited a lower risk of depressive symptoms in males. Dietary patterns, including Paleolithic and Mediterranean diets, showcased potential protective effects against depression, anxiety, and stress. The ketogenic diet revealed promise in ameliorating depression and psychosis symptoms alongside positive metabolic changes. Fasting interventions, though challenging, were associated with lower anxiety and depression levels without increased fatigue. Bright white light therapy enhanced remission rates and reduced depression scores in bipolar depression. Probiotic supplementation exhibited potential in reducing depression scores and improving metabolic markers, although further investigation is warranted. Conclusion: The diverse array of interventions explored in this study underlines the multifaceted nature of depression treatment. While these findings offer hope for more personalized and effective approaches, it is imperative to consider the variability in study designs, sample sizes, and methodologies among the selected papers. The mechanisms underlying the observed effects remain partially understood, emphasizing the need for continued mechanistic research. This study sets the stage for future investigations and clinical practices, showcasing the potential of various interventions in mitigating the challenges posed by depression and paving the way for more effective treatment strategies.
Medicine and Pharmacology, Psychiatry and Mental Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
