Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Zn Bioaccessibility in the Large Intestine of Foodstuffs after in Vitro Digestion and Fermentation with Fecal Material of Children with Gluten Related Disorders, Obesity, and Allergy/Intolerance to Cow’s Milk Proteins

Úrsula García-Conde
,
Miguel Navarro-Alarcón
* ORCID logo ,
Beatriz Navajas-Porras
ORCID logo ,
Daniel Hinojosa-Nogueira
ORCID logo ,
Adriana Delgado-Osorio
ORCID logo ,
Sergio Pérez-Burillo
,
Miguel Navarro-Moreno
,
Silvia Pastoriza
,
Konstantinos Douros
ORCID logo ,
José Ángel Rufián-Henares
ORCID logo
Version 1 : Received: 18 September 2023 / Approved: 19 September 2023 / Online: 20 September 2023 (09:41:01 CEST)

How to cite: García-Conde, Ú.; Navarro-Alarcón, M.; Navajas-Porras, B.; Hinojosa-Nogueira, D.; Delgado-Osorio, A.; Pérez-Burillo, S.; Navarro-Moreno, M.; Pastoriza, S.; Douros, K.; Rufián-Henares, J.Á. Zn Bioaccessibility in the Large Intestine of Foodstuffs after in Vitro Digestion and Fermentation with Fecal Material of Children with Gluten Related Disorders, Obesity, and Allergy/Intolerance to Cow’s Milk Proteins. Preprints 2023, 2023091377. https://doi.org/10.20944/preprints202309.1377.v1 García-Conde, Ú.; Navarro-Alarcón, M.; Navajas-Porras, B.; Hinojosa-Nogueira, D.; Delgado-Osorio, A.; Pérez-Burillo, S.; Navarro-Moreno, M.; Pastoriza, S.; Douros, K.; Rufián-Henares, J.Á. Zn Bioaccessibility in the Large Intestine of Foodstuffs after in Vitro Digestion and Fermentation with Fecal Material of Children with Gluten Related Disorders, Obesity, and Allergy/Intolerance to Cow’s Milk Proteins. Preprints 2023, 2023091377. https://doi.org/10.20944/preprints202309.1377.v1

Abstract

Zn is an essential element for children related to optimal growth, development and nutritional metabolism. We measured Zn bioaccesibility (Zn-BA) levels of foods by Inductively coupled plasma mass spectrometry (ICP-MS) after in vitro digestion-fermentation method from children with gluten related disorders (GRD-CH), obesity (OB-CH) and allergy/intolerance to cow’s milk proteins (AICM-CH). Zn-BA levels in sick children (34.7 ± 28.8, 29.6 ± 30.1 and 26.7 ± 30.4%, respectively) were significantly lower (p < 0.05) than in healthy norm-weight children (HE-CH). For AICM-CH, Zn-BA in animal foods was significantly lower than in plant foods, and in both plant and animal foods from sick and healthy children (p < 0.05). In foods of animal origin in sick and healthy children, Zn-BA in foods heated in liquid media (frying and boiling) was significantly higher than in foods heated by hot air (roasting and grilling). In conclusion, in children the studied diseases diminished the Zn-BA, probably by the alteration of the gut microbiota which could negatively affect their appropriate long-term development. In AICM-CH, the allergy to cow's milk proteins could induce intestinal dysbiosis and inflammatory processes, leading to allergies to other animal food proteins, and to a more pronounced decrease of Zn-BA.

Keywords

bioaccesibility; released Zn amounts from foods; children; gluten related disorders; obesity; allergy/intolerance to cow’s milk proteins; raw and cooked foods

Subject

Public Health and Healthcare, Public Health and Health Services

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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