Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Early ENT Manifestations in Eosinophilic Granulomatosis with Poliangioitis: Results from Our Cohort Group and Literature Review

Mario D’Onofrio
,
Daniele La Prova
,
Maria Rosaria Galdiero
ORCID logo ,
Elena Cantone
ORCID logo ,
Eugenio Tremante
,
Vittoria Barbieri
,
Claudio Di Nola
,
Giuseppe Spadaro
,
Amato De Paulis
ORCID logo ,
Aikaterini Detoraki
* ORCID logo
Version 1 : Received: 15 September 2023 / Approved: 19 September 2023 / Online: 20 September 2023 (07:36:05 CEST)

A peer-reviewed article of this Preprint also exists.

D’Onofrio, M.; La Prova, D.; Galdiero, M.R.; Cantone, E.; Tremante, E.; Mascolo, M.; Barbieri, V.; Di Nola, C.; Spadaro, G.; de Paulis, A.; Detoraki, A. Early Ear, Nose and Throat Manifestations in Eosinophilic Granulomatosis with Poliangioitis: Results from Our Cohort Group and Literature Review. J. Clin. Med. 2023, 12, 6967. D’Onofrio, M.; La Prova, D.; Galdiero, M.R.; Cantone, E.; Tremante, E.; Mascolo, M.; Barbieri, V.; Di Nola, C.; Spadaro, G.; de Paulis, A.; Detoraki, A. Early Ear, Nose and Throat Manifestations in Eosinophilic Granulomatosis with Poliangioitis: Results from Our Cohort Group and Literature Review. J. Clin. Med. 2023, 12, 6967.

Abstract

Eosinophilic Granulomatosis with Polyangiitis (EGPA) is a rare systemic necrotizing vasculitis, affecting small-to-medium sized vessels. EGPA’s clinical manifestations are heterogeneous affecting different organs and systems and the upper respiratory tract can be affected with Ear, Nose and Throat (ENT) involvement. The aim of our study was to assess type manifestations at time of diagnosis in a cohort of EGPA patients and correlate findings with baseline variables (sex, age, antineutrophil cytoplasmic antibodies –ANCA- status) and literature reports. Main ENT manifestations in our patients at time of diagnosis were: nasal polyposis (CRSwNP) (52%), turbinate hypertrophy (48%), nasal swelling (40%), rhinorrhoea (40%), chronic rhinosinusitis without nasal polyposis (CRSsNP) (32%), nasal bone deformities (32%), nasal crusts (20%), nasal mucosal ulcers (12%), corditis (12%), hoarseness/dysphonia (12%), hearing loss (12%), mucoceles(4%) eosinophilic rhinitis (4%). No correlations were found between sex, age, ANCA status and ENT clinical manifestations. A polymorphic ENT involvement is often observed at early stages of EGPA. The presence of nasal, sinus, ear and/or laryngeal manifestations in patients with asthma and hypereosinophilia, independently of sex, age or ANCA status, should raise allert for further investigation and differential diagnosis for EGPA. ENT specialists should be aware of their leading position in this diagnostic race.

Keywords

eosinophilic granulomatosis with polyangiitis; EGPA; ENT; rhinosinusitis; CRSwNP; hearing loss; otitis; ANCA; vasculitis

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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