Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Zoon’s Balanitis as a Separate Type of Balanitis with the Characteristic Pattern of Pro-Inflammatory Cytokines Expression

Mateusz Czajkowski
* ORCID logo ,
Katarzyna Czajkowska
,
Piotr M. Wierzbicki
ORCID logo ,
Anna Kotulak-Chrząszcz
,
Małgorzata Sokołowska-Wojdyło
ORCID logo ,
Marzena Kogut-Wierzbicka
,
Zbigniew Kmieć
ORCID logo ,
Marcin Matuszewski
Version 1 : Received: 18 September 2023 / Approved: 19 September 2023 / Online: 20 September 2023 (05:42:58 CEST)

How to cite: Czajkowski, M.; Czajkowska, K.; Wierzbicki, P.M.; Kotulak-Chrząszcz, A.; Sokołowska-Wojdyło, M.; Kogut-Wierzbicka, M.; Kmieć, Z.; Matuszewski, M. Zoon’s Balanitis as a Separate Type of Balanitis with the Characteristic Pattern of Pro-Inflammatory Cytokines Expression. Preprints 2023, 2023091344. https://doi.org/10.20944/preprints202309.1344.v1 Czajkowski, M.; Czajkowska, K.; Wierzbicki, P.M.; Kotulak-Chrząszcz, A.; Sokołowska-Wojdyło, M.; Kogut-Wierzbicka, M.; Kmieć, Z.; Matuszewski, M. Zoon’s Balanitis as a Separate Type of Balanitis with the Characteristic Pattern of Pro-Inflammatory Cytokines Expression. Preprints 2023, 2023091344. https://doi.org/10.20944/preprints202309.1344.v1

Abstract

Zoon balanitis (ZB) is a mild and chronic inflammatory dermatosis that mostly affects uncircumcised men of middle and old age. The etiology of this disease remains unknown. Moreover, some authors have questioned the presence of this type of balanitis. Our study aimed to assess the expression of proinflammatory cytokines in ZB and demonstrate the presence of a characteristic expression pattern, different from that reported in the literature for penile lichen sclerosus(LS) and penile cancer. Skin biopsies from four foreskins affected by Zoon’s balanitis with surrounding morphologically unchanged skin and 13 from nonlesional foreskins (healthy control adult males undergoing circumcision) were obtained. RNA was extracted from each biopsy, followed by quantitative assessment of the gene expression of interleukin 1-A(IL-1A), interleukin 1-B(IL-1B),interleukin 1 receptor antagonist(IL-1RN),interleukin 6(IL-6), transforming growth factor β1(TGF-β1), and interferon-gamma(INF-γ). The decreased level of IL-1A mRNA was observed in Zoon’s balanitis in both inflamed and healthy skin compared to control samples. There were no statistically significant differences in other investigated cytokines gene expression between Zoon’s balanitis and the control group. In conclusion, the expression of proinflammatory cytokines was not related to the course of zoon balanitis. Moreover, in the case of IL-1A, we observed the suppression of the immune response.

Keywords

zoon balanitis; IL‑1; IL‑1RN; IL‑6; IFN‑γ; TGF‑β1

Subject

Medicine and Pharmacology, Urology and Nephrology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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