Version 1
: Received: 15 September 2023 / Approved: 15 September 2023 / Online: 18 September 2023 (07:02:09 CEST)
How to cite:
Errigo, A.; Dore, M. P.; Pes, G. M. Association of Genetic Polymorphisms with Longevity in the population of the Sardinian Blue Zone. Preprints2023, 2023091070. https://doi.org/10.20944/preprints202309.1070.v1
Errigo, A.; Dore, M. P.; Pes, G. M. Association of Genetic Polymorphisms with Longevity in the population of the Sardinian Blue Zone. Preprints 2023, 2023091070. https://doi.org/10.20944/preprints202309.1070.v1
Errigo, A.; Dore, M. P.; Pes, G. M. Association of Genetic Polymorphisms with Longevity in the population of the Sardinian Blue Zone. Preprints2023, 2023091070. https://doi.org/10.20944/preprints202309.1070.v1
APA Style
Errigo, A., Dore, M. P., & Pes, G. M. (2023). Association of Genetic Polymorphisms with Longevity in the population of the Sardinian Blue Zone. Preprints. https://doi.org/10.20944/preprints202309.1070.v1
Chicago/Turabian Style
Errigo, A., Maria Pina Dore and Giovanni Mario Pes. 2023 "Association of Genetic Polymorphisms with Longevity in the population of the Sardinian Blue Zone" Preprints. https://doi.org/10.20944/preprints202309.1070.v1
Abstract
Background. In the central-eastern region of the Mediterranean island of Sardinia more than two decades ago, a mountain area was identified where the population displays exceptional longevity, especially among men (the longevity Blue Zone, LBZ). This community was thoroughly investigated seeking to understand the underlying factors of this phenomenon. In the present study, 11 genetic markers previously associated with longevity in several long-lived populations were analyzed. Methods. APOE (rs429358 and rs7412), APOE promoter (rs449647, rs769446, and rs405509), ACE1 (rs1799752), IL6 ‒174G/C (rs1800795), TNFα ‒308G/A (rs1800629), FOXO3A (rs2802292), KLOTHO (rs9536314) and G6PD (c.563C→T) were investigated. PCR-based genotyping was performed following genomic DNA extraction from 150 nonagenarians living in the LBZ and 150 controls from a nearby area. Results. No significant deviation of the frequency of the analyzed markers was detected between the two groups except a weak association with the –174G>C gene variant of the IL-6 gene (p=0.040), a major modulator of the inflammatory response. Conclusions. The findings of this study do not support a significant association of known genetic variants on survival in the population of the Sardinian LBZ. Other genetic or epigenetic traits might play a role not yet identified.
Keywords
human longevity; single nucleotide polymorphisms; Sardinia
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
