Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Listeria monocytogenes ST37 Distribution in Russia and Properties of the Clinical and Food-Born Isolates

Olga L. Voronina
* ORCID logo ,
Marina S. Kunda
,
Natalia N. Ryzhova
,
Ekaterina I. Aksenova
,
Margarita A. Kustova
,
Tatyana I. Karpova
,
Alina R Melkumyan
,
Elena A. Klimova
,
Olga A. Gruzdeva
ORCID logo ,
Igor S. Tartakovsky
Version 1 : Received: 13 September 2023 / Approved: 14 September 2023 / Online: 14 September 2023 (14:51:01 CEST)

A peer-reviewed article of this Preprint also exists.

Voronina, O.L.; Kunda, M.S.; Ryzhova, N.N.; Aksenova, E.I.; Kustova, M.A.; Karpova, T.I.; Melkumyan, A.R.; Klimova, E.A.; Gruzdeva, O.A.; Tartakovsky, I.S. Listeria monocytogenes ST37 Distribution in the Moscow Region and Properties of Clinical and Foodborne Isolates. Life 2023, 13, 2167. Voronina, O.L.; Kunda, M.S.; Ryzhova, N.N.; Aksenova, E.I.; Kustova, M.A.; Karpova, T.I.; Melkumyan, A.R.; Klimova, E.A.; Gruzdeva, O.A.; Tartakovsky, I.S. Listeria monocytogenes ST37 Distribution in the Moscow Region and Properties of Clinical and Foodborne Isolates. Life 2023, 13, 2167.

Abstract

Listerias of the phylogenetic lineage II (PLII) are common in the European environment, and are hypovirulent. Despite this, they caused more than a third of sporadic cases of listeriosis, and multi-country foodborne outbreaks. L. monocytogenes ST37 is one of them. During the COVID-19 pandemic ST37 appeared in the clinical cases and ranked second in occurrence among food isolates in the Moscow region. The aim of this study was to describe the genomic features of ST37 isolates from different sources. All clinical cases of ST37 were in the cohort of male patients (age, 48-81 years) with meningitis-septicemia manifestation, and COVID-19 or Influenza in the anamnesis. The core genomes of the fish isolates were closely related. The clinical and meat isolates revealed a large diversity. Prophages (2-4/genome) were the source of the unique genes. Two clinical isolates displayed the pseudolysogeny, and excided prophages were A006-like. Absence of the plasmids, the assortment of virulence factors and resistance determinants in chromosome corresponded to the hypovirulent characteristics. However, all clinical isolates caused severe disease with deaths in four cases. Thus, these studies allow us to speculate that a previous viral infection increases a human susceptibility to listeriosis.

Keywords

Listeria monocytogenes; food-born pathogen; invasive listeriosis; cgMLST; whole genome sequencing; prophages; virulence factors; COVID-19.

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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