Four New Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata and DFT-Based Structure Elucidation

Dan-Dan Yu; Lin-Mao Ke; Jiao Liu; Song-Wei Li; Ming-Zhi Su; Li-Gong Yao; Hui Luo; Yue-Wei Guo

doi:10.20944/preprints202309.0803.v1

A peer-reviewed article of this Preprint also exists.

Yu, D.-D.; Ke, L.-M.; Liu, J.; Li, S.-W.; Su, M.-Z.; Yao, L.-G.; Luo, H.; Guo, Y.-W. Four New Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata and DFT-Based Structure Elucidation. Molecules 2023, 28, 6892. Yu, D.-D.; Ke, L.-M.; Liu, J.; Li, S.-W.; Su, M.-Z.; Yao, L.-G.; Luo, H.; Guo, Y.-W. Four New Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata and DFT-Based Structure Elucidation. Molecules 2023, 28, 6892.

Abstract

Three new cembranoids (1–3) and a new casbanoid (4), along with three known analogues (5–7), have been isolated from the soft coral Sinularia nanolobata collected off Ximao Island. The structures including the absolute configurations of new compounds were established by extensive spectro-scopic data analysis, time-dependent density functional theory/electronic circular dichroism (TDDFT-ECD) calculations and the comparison with spectroscopic data of known compounds. In in vitro bioassay, compounds 1 and 5 exhibited moderate cytotoxic activities against human erythroleukemia (HEL) cells line with IC50 values of 37.1 and 42.4 uM, respectively.

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Four New Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata and DFT-Based Structure Elucidation

Abstract

Keywords

Subject

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