Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Crosstalk between Exercise-Derived Endocannabinoidome and Kynurenines: Potential Target Therapies against Obesity and Depression Symptoms

Tiffany Wences-Chirino
ORCID logo ,
Edgar Rangel-López
ORCID logo ,
Alexandra Luna-Angulo
,
Paul Carrillo-Mora
,
Carlos Landa-Solis
,
María Alejandra Samudio-Cruz
,
Alim Caelli Fuentes-Bello
,
Rogelio Paniagua-Pérez
,
Juan Ríos-Martínez
,
Laura Sánchez-Chapul
*
Version 1 : Received: 7 September 2023 / Approved: 11 September 2023 / Online: 12 September 2023 (16:51:21 CEST)

A peer-reviewed article of this Preprint also exists.

Wences Chirino, T.; Rangel López, E.; Luna Angulo, A.; Carrillo Mora, P.; Landa Solis, C.; Samudio Cruz, M.A.; Fuentes Bello, A.C.; Paniagua Pérez, R.; Ríos Martínez, J.; Sánchez Chapul, L. Crosstalk between Exercise-Derived Endocannabinoidome and Kynurenines: Potential Target Therapies for Obesity and Depression Symptoms. Pharmaceuticals 2023, 16, 1421. Wences Chirino, T.; Rangel López, E.; Luna Angulo, A.; Carrillo Mora, P.; Landa Solis, C.; Samudio Cruz, M.A.; Fuentes Bello, A.C.; Paniagua Pérez, R.; Ríos Martínez, J.; Sánchez Chapul, L. Crosstalk between Exercise-Derived Endocannabinoidome and Kynurenines: Potential Target Therapies for Obesity and Depression Symptoms. Pharmaceuticals 2023, 16, 1421.

Abstract

The kynurenine pathway (KP) and the endocannabinoid system (ECS) are known to be deregulated in depression and obesity; however, it has been recognized that acute physical exercise has an important modulating role inducing changes in the mobilization of their respective metabolites -endocannabinoids (eCB) and kynurenines (KYN)- which overlap at some points, acting as im-portant antidepressant, anti-nociceptive, anti-inflammatory, and antioxidant biomarkers. There-fore, the aim of this review is to analyze and discuss some studies performed recently to investigate the potential interactions between both systems, particularly, those related with exercise-derived endocannabinoidome and kynurenine mechanisms and to elucidate how, the prescription of physical exercise could represent a new approach for the clinical manage of these two conditions.

Keywords

exercise; endocannabinoids; kynurenines; obesity; depression

Subject

Public Health and Healthcare, Physical Therapy, Sports Therapy and Rehabilitation

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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